CAS No. 850140-73-7
Batch:
Purity:99.89
Chemical Structure
Check the
Afatinib Dimaleate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | bis((Z)-but-2-enedioic acid);(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide | |
|---|---|---|
| CAS Number | 850140-73-7 | |
| Molecular Formula |
C24H25ClFN5O3.2C4H4O4 |
|
| Molecular Weight (MW) | 717.18 | |
| SMILES | CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O | |
| InChIKey | USNRYVNRPYXCSP-JUGPPOIOSA-N |
Afatinib Dimaleate is an irreversible dual EGFR and HER2 inhibitor that targets wild-type EGFR, EGFR L858R, EGFR L858R/T790M, and HER2. By suppressing receptor autophosphorylation and downstream signaling pathways, it inhibits cellular proliferation in gefitinib-resistant cancer models and induces autophagy. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(139.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(139.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(139.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 50 mg/mL |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(139.43 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Afatinib Dimaleate Clinical Trials
- Afatinib Dimaleate Solubility in DMSO
- Afatinib Dimaleate Stock Solution
- Afatinib Dimaleate Storage
- Afatinib Dimaleate Stability
- Afatinib Dimaleate Molecular Weight
- Afatinib Dimaleate SMILES
- Afatinib Dimaleate Chemical Structure (2D and 3D)
- Afatinib Dimaleate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.