CAS No. 34240-05-6

Batch: Purity:99.86
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ADOX (Adenosine Dialdehyde) Chemical Structure
Chemical Structure
Check the ADOX (Adenosine Dialdehyde) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[1-(6-aminopurin-9-yl)-2-oxoethoxy]-3-hydroxypropanal
CAS Number 34240-05-6
Molecular Formula

C10H11N5O4
Molecular Weight (MW) 265.23
SMILES C1=NC(=C2C(=N1)N(C=N2)C(C=O)OC(CO)C=O)N
InChIKey ILMNSCQOSGKTNZ-UHFFFAOYSA-N

Ordering Information

Biological Activity

ADOX (Adenosine Dialdehyde) is an adenosine analog that functions as a potent S-adenosylmethionine-dependent methyltransferase inhibitor. By directly targeting S-adenosylhomocysteine hydrolase, ADOX elevates intracellular S-adenosylhomocysteine levels, thereby disrupting critical transmethylation processes. Consequently, this blockade impairs downstream protein and histone methylation, suppressing gene expression, cellular proliferation, and oncogenic signaling pathways in experimental cell models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 19 mg/mL (71.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.