CAS No. 321-30-2
| IUPAC Name | bis(7H-purin-6-amine);sulfuric acid | |
|---|---|---|
| CAS Number | 321-30-2 | |
| Molecular Formula |
2(C5H5N5).H2SO4 |
|
| Molecular Weight (MW) | 368.33 | |
| SMILES | C1=NC2=NC=NC(=C2N1)N.C1=NC2=NC=NC(=C2N1)N.OS(=O)(=O)O | |
| InChIKey | LQXHSCOPYJCOMD-UHFFFAOYSA-N |
Adenine sulfate is a purine derivative and salt form of adenine that acts as an essential nucleobase for nucleic acid synthesis and cellular energy transfer. In vivo, dietary administration of adenine leads to the accumulation of insoluble 2,8-dihydroxyadenine in renal tubules, triggering extensive tubular damage, inflammation, and tubulointerstitial fibrosis. Consequently, adenine sulfate is widely utilized to induce robust rodent models of chronic kidney disease and tubulointerstitial nephropathy. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| Water | 2 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 2 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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