CAS No. 1467093-03-3
| IUPAC Name | N-[5-[3-[7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl]-3-pyridinyl]-3-methylbutanamide | |
|---|---|---|
| CAS Number | 1467093-03-3 | |
| Molecular Formula |
C29H24FN7O |
|
| Molecular Weight (MW) | 505.55 | |
| SMILES | CC(C)CC(=O)NC1=CN=CC(=C1)C2=CC3=C(C=C2)NN=C3C4=NC5=C(N4)C=NC=C5C6=CC(=CC=C6)F | |
| InChIKey | AQDWDWAYVBQMAM-UHFFFAOYSA-N |
Adavivint (SM04690) is a potent and specific inhibitor of canonical Wnt signaling that inhibits TCF/LEF reporter activity. By blocking Wnt/β-catenin signaling, adavivint modulates downstream transcriptional cascades, suppressing catabolic gene expression and promoting chondrocyte differentiation. Consequently, it induces chondrogenesis, reduces cartilage degradation, and protects joint integrity in cellular and preclinical animal models of osteoarthritis. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(59.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- Adavivint (SM04690) Clinical Trials
- Adavivint (SM04690) Solubility in DMSO
- Adavivint (SM04690) Stock Solution
- Adavivint (SM04690) Storage
- Adavivint (SM04690) Stability
- Adavivint (SM04690) Molecular Weight
- Adavivint (SM04690) SMILES
- Adavivint (SM04690) Chemical Structure (2D and 3D)
- Adavivint (SM04690) SDS｜MSDS