CAS No. 1375465-91-0
| IUPAC Name | N-hydroxy-2-[(1-phenylcyclopropyl)amino]pyrimidine-5-carboxamide | |
|---|---|---|
| CAS Number | 1375465-91-0 | |
| Molecular Formula |
C14H14N4O2 |
|
| Molecular Weight (MW) | 270.29 | |
| SMILES | C1CC1(C2=CC=CC=C2)NC3=NC=C(C=N3)C(=O)NO | |
| InChIKey | LIIWIMDSZVNYHY-UHFFFAOYSA-N |
ACY-738 is a selective histone deacetylase 6 (HDAC6) inhibitor displaying 60- to 1500-fold selectivity over class I HDACs. Targeted inhibition of HDAC6 increases α-tubulin acetylation without altering histone acetylation, modulating microtubule dynamics and axonal transport. Consequently, ACY-738 promotes neuroprotective downstream responses, rescues axonal transport deficits, and modulates neurobehavioral and neuroinflammatory phenotypes in preclinical models. [1]
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Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
| DMSO |
54 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 1 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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