CAS No. 185106-16-5
Batch:
Purity:99.01
Chemical Structure
Check the
Acotiamide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide | |
|---|---|---|
| CAS Number | 185106-16-5 | |
| Molecular Formula |
C21H30N4O5S |
|
| Molecular Weight (MW) | 450.55 | |
| SMILES | CC(C)N(CCNC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2O)OC)OC)C(C)C | |
| InChIKey | TWHZNAUBXFZMCA-UHFFFAOYSA-N |
Biological Activity
Acotiamide (Z388) is a novel acetylcholinesterase inhibitor that exhibits potent fundus-relaxing and gastroprokinetic properties. By selectively inhibiting acetylcholinesterase activity in the enteric nervous system, acotiamide prevents the degradation of endogenous acetylcholine. This enhancement of cholinergic transmission downstream promotes gastric fundus relaxation, accelerates gastric motility, and restores impaired gastric accommodation without affecting gastrointestinal hormone secretion.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
90 mg/mL
(199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 38 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Note: Technical data last updated: Sep 1, 2026.