CAS No. 840506-29-8

Batch: Purity:99.84
Check CoA
Acelarin (NUC-1031) Chemical Structure
Chemical Structure
Check the Acelarin (NUC-1031) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name benzyl (2S)-2-[[[(2R,3R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
CAS Number 840506-29-8
Molecular Formula

C25H27F2N4O8P
Molecular Weight (MW) 580.47
SMILES CC(C(=O)OCC1=CC=CC=C1)NP(=O)(OCC2C(C(C(O2)N3C=CC(=NC3=O)N)(F)F)O)OC4=CC=CC=C4
InChIKey NHTKGYOMICWFQZ-KKQYNPQSSA-N

Biological Activity

Acelarin (NUC-1031) is a nucleotide analog and potent DNA synthesis inhibitor designed as a phosphoramidate ProTide transformation of gemcitabine. It bypasses key cancer cell resistance mechanisms associated with gemcitabine uptake and activation, leading to the inhibition of DNA replication and induction of apoptosis. This intracellular activation reduces cancer cell proliferation and inhibits tumor growth across various preclinical cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (172.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 20 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Slusarczyk M, et al. J Med Chem. 2014;57(4):1531-42.

Jump to

Note: Technical data last updated: Sep 1, 2026.