CAS No. 136470-78-5
Batch:
Purity:99.98
Chemical Structure
Check the
Abacavir
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 136470-78-5 | |
|---|---|---|
| Molecular Formula |
C14H18N6O |
|
| Molecular Weight (MW) | 286.33 | |
| SMILES | C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO |
Biological Activity
Abacavir is a nucleoside analog reverse transcriptase inhibitor (NRTI) that targets human immunodeficiency virus type 1 reverse transcriptase. Intracellularly converted into its active metabolite, carbovir triphosphate, it competes with endogenous deoxyguanosine triphosphate for incorporation into viral DNA. This incorporation leads to viral DNA chain termination, thereby suppressing viral cDNA synthesis and inhibiting viral replication in host cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(199.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | Insoluble |
| DMSO |
57 mg/mL
(199.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.