CAS No. 899431-18-6
| IUPAC Name | 3-[[5-(2,3-dichlorophenyl)tetrazol-1-yl]methyl]pyridine;hydrochloride | |
|---|---|---|
| CAS Number | 899431-18-6 | |
| Molecular Formula |
C13H10Cl3N5 |
|
| Molecular Weight (MW) | 342.61 | |
| SMILES | C1=CC(=C(C(=C1)Cl)Cl)C2=NN=NN2CC3=CN=CC=C3.Cl | |
| InChIKey | MBTJFFMIPPMRGR-UHFFFAOYSA-N |
A-438079 Hydrochloride is a potent and selective P2X7 receptor antagonist with a pIC50 of 6.9. Inhibition of P2X7 receptor signaling blocks ATP-stimulated pore formation, intracellular calcium influx, and the release of pro-inflammatory cytokines such as interleukin-1β. Downstream suppression of P2X7-mediated pathways attenuates neuroinflammation and suppresses nociceptive transmission and neuronal hypersensitivity in inflammatory and neuropathic pain states. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(198.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 68 mg/mL |
| Water | 10 mg/mL (超声加热十分钟) |
| DMSO |
68 mg/mL
(198.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 68 mg/mL |
| Ethanol | 68 mg/mL |
| DMSO |
61 mg/mL
(178.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 61 mg/mL |
| Ethanol | 20 mg/mL |
| DMSO |
69 mg/mL
(201.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 69 mg/mL |
| Ethanol | 4 mg/mL |
| DMSO |
69 mg/mL
(201.39 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 69 mg/mL |
| Ethanol | 69 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
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- A-438079 Hydrochloride Mechanism of Action: P2X7 Receptor Inhibition in Microglial Cell Research
- A-438079 Hydrochloride Working Concentration | Cell Culture | Treatment
- A-438079 Hydrochloride Solubility in DMSO
- A-438079 Hydrochloride Stock Solution
- A-438079 Hydrochloride Storage
- A-438079 Hydrochloride Stability
- A-438079 Hydrochloride Combination Database
- A-438079 Hydrochloride Molecular Weight
- A-438079 Hydrochloride SMILES
- A-438079 Hydrochloride Chemical Structure (2D and 3D)
- A-438079 Hydrochloride Sigma (A9736)? Try a better option.
- A-438079 Hydrochloride MedChemExpress (HY-15488A)? Try a better option.
- A-438079 Hydrochloride Cayman (14580)? Try a better option.
- A-438079 Hydrochloride Tocris (2972)? Try a better option.
- A-438079 Hydrochloride APExBIO (A3130)? Try a better option.
- A-438079 Hydrochloride SDS｜MSDS