CAS No. 1235034-55-5(free base)
| IUPAC Name | 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-5-[3-[4-[3-(dimethylamino)prop-1-ynyl]-2-fluorophenoxy]propyl]-1,3-thiazole-4-carboxylic acid | |
|---|---|---|
| CAS Number | 1235034-55-5(free base) | |
| Molecular Formula |
C35H34Cl2FN5O4S2 |
|
| Molecular Weight (MW) | 742.71 | |
| SMILES | CN(C)CC#CC1=CC(=C(C=C1)OCCCC2=C(N=C(S2)N3CCC4=C(C3)C(=CC=C4)C(=O)NC5=NC6=CC=CC=C6S5)C(=O)O)F | |
| InChIKey | SOYCFODXNRVBTI-UHFFFAOYSA-N |
A-1155463 Dihydrochloride is a potent and selective BCL-XL inhibitor that exhibits high selectivity over other BCL-2 family proteins, such as BCL-2 and MCL-1. By disrupting interactions with pro-apoptotic proteins, it blocks BCL-XL anti-apoptotic activity, triggering mitochondrial outer membrane permeabilization and inducing apoptosis in BCL-XL-dependent cancer cells. This agent effectively impairs cell viability and enhances sensitivity to chemotherapeutic agents in preclinical cancer models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(134.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(134.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
| DMSO |
100 mg/mL
(134.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(134.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- A-1155463 Dihydrochloride Solubility in DMSO
- A-1155463 Dihydrochloride Stock Solution
- A-1155463 Dihydrochloride Storage
- A-1155463 Dihydrochloride Stability
- A-1155463 Dihydrochloride Molecular Weight
- A-1155463 Dihydrochloride SMILES
- A-1155463 Dihydrochloride Chemical Structure (2D and 3D)
- A-1155463 Dihydrochloride SDS｜MSDS