Molecular Weight: 272.09 g/mol

Zoledronic acid (Zoledronate) Chemical Structure
Chemical Structure
Check the Zoledronic acid (Zoledronate) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
0.1M NAOH 25 mg/mL (Ultrasonic and heating for 5 minutes.)
Water 0.5 mg/mL (Warmed with 50℃ water bath; Ultrasonicated)
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Aliquotting Service

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Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.

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Chemical Information

IUPAC Name (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
CAS Number 118072-93-8
Molecular Formula

C5H10N2O7P2
Molecular Weight (MW) 272.09
SMILES C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
InChIKey XRASPMIURGNCCH-UHFFFAOYSA-N

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Note: Technical data last updated: Sep 1, 2026.