CAS No. 111406-87-2

Batch: Purity:99.98
Check CoA
Zileuton Chemical Structure
Chemical Structure
Check the Zileuton product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
CAS Number 111406-87-2
Molecular Formula

C11H12N2O2S
Molecular Weight (MW) 236.29
SMILES CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O
InChIKey MWLSOWXNZPKENC-UHFFFAOYSA-N

Biological Activity

Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that effectively blocks the biosynthesis of leukotrienes, including LTB4, LTC4, LTD4, and LTE4. By suppressing the 5-LOX enzymatic pathway, Zileuton attenuates leukotriene-mediated inflammatory responses and airway hyperresponsiveness. Furthermore, Zileuton has been shown to induce cellular apoptosis while simultaneously protecting against ferroptotic cell death, thereby modulating downstream survival and inflammatory pathways. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 47 mg/mL (198.9 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 47 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Carter GW, et al. J Pharmacol Exp Ther. 1991;256(3):929-37.

[2] Bell RL, et al. Int J Immunopharmacol. 1992;14(3):505-10.

Jump to

Note: Technical data last updated: Sep 1, 2026.