CAS No. 475110-96-4
Batch:
Purity:99.98
Chemical Structure
Check the
ZSTK474
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[4-[2-(difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine | |
|---|---|---|
| CAS Number | 475110-96-4 | |
| Molecular Formula |
C19H21F2N7O2 |
|
| Molecular Weight (MW) | 417.41 | |
| SMILES | C1COCCN1C2=NC(=NC(=N2)N3C4=CC=CC=C4N=C3C(F)F)N5CCOCC5 | |
| InChIKey | HGVNLRPZOWWDKD-UHFFFAOYSA-N |
Biological Activity
ZSTK474 is a pan-class I PI3K inhibitor targeting PI3Kγ (IC50 6 nM), PI3Kα (IC50 17 nM), PI3Kδ (IC50 37 nM), and PI3Kβ (IC50 53 nM). By inhibiting class I phosphatidylinositol 3-kinases, it attenuates downstream AKT/mTOR signaling pathways, resulting in cell cycle arrest and cellular growth inhibition. In animal models, oral administration of ZSTK474 exerts significant antitumor activity against human cancer xenografts with manageable toxicity.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(35.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
21 mg/mL
(50.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
21 mg/mL
(50.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
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Note: Technical data last updated: Sep 1, 2026.