CAS No. 49671-76-3
| IUPAC Name | 2-(4-tert-butylphenyl)-1H-benzimidazole | |
|---|---|---|
| CAS Number | 49671-76-3 | |
| Molecular Formula |
C17H18N2 |
|
| Molecular Weight (MW) | 250.34 | |
| SMILES | CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3N2 | |
| InChIKey | LQUNNCQSFFKSSK-UHFFFAOYSA-N |
ZLN005 is a potent and tissue-specific transcriptional activator of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). It selectively upregulates PGC-1α gene expression, which promotes downstream mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation. In skeletal muscle and hepatic models, ZLN005 enhances cellular energy metabolism, suppresses gluconeogenesis, and improves glucose tolerance and insulin sensitivity. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(199.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
| DMSO |
37 mg/mL
(147.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
50 mg/mL
(199.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 12 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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