CAS No. 541503-81-5
Batch:
Purity:99.39
Chemical Structure
Check the
Vicriviroc Malate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | (4,6-dimethylpyrimidin-5-yl)-[4-[(3S)-4-[(1R)-2-methoxy-1-[4-(trifluoromethyl)phenyl]ethyl]-3-methylpiperazin-1-yl]-4-methylpiperidin-1-yl]methanone;2-hydroxybutanedioic acid | |
|---|---|---|
| CAS Number | 541503-81-5 | |
| Molecular Formula |
C28H38F3N5O2.C4H6O5 |
|
| Molecular Weight (MW) | 667.72 | |
| SMILES | COCC(N1CCN(CC1C)C2(C)CCN(CC2)C(=O)C3=C(C)N=CN=C3C)C4=CC=C(C=C4)C(F)(F)F.OC(CC(O)=O)C(O)=O | |
| InChIKey | HQJIGHNTROUVLT-RIAYWLAYSA-N |
Biological Activity
Vicriviroc Malate is a potent CCR5 antagonist with an IC50 of. It disrupts receptor-mediated downstream pathways by inhibiting chemokine-induced chemotaxis and RANTES-stimulated GTPγS binding with a mean IC50 ofin CCR5-expressing cells. Through these mechanism-based effects on coreceptor activation, Vicriviroc displays broad-spectrum antiviral activity against genetically diverse HIV-1 isolates, including multidrug-resistant strains. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(149.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.