CAS No. 443913-73-3

Batch: Purity:99.99
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Vandetanib (ZD6474) Chemical Structure
Chemical Structure
Check the Vandetanib (ZD6474) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
CAS Number 443913-73-3
Molecular Formula

C22H24BrFN4O2
Molecular Weight (MW) 475.35
SMILES CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
InChIKey UHTHHESEBZOYNR-UHFFFAOYSA-N

Ordering Information

Biological Activity

Vandetanib (ZD6474) is a multi-targeted tyrosine kinase inhibitor that potently inhibits VEGFR2 (IC50 40 nM), VEGFR3 (IC50 110 nM), and EGFR (IC50 500 nM). It suppresses endothelial cell proliferation (IC50 60 nM) and blocks tumor angiogenesis. Furthermore, vandetanib increases reactive oxygen species levels to induce apoptosis and autophagy, thereby suppressing tumor growth and metastasis in preclinical cancer models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (126.22 mM) ; Warmed with 60°C water bath ; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.