CAS No. 137862-53-4
| IUPAC Name | (2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid | |
|---|---|---|
| CAS Number | 137862-53-4 | |
| Molecular Formula |
C24H29N5O3 |
|
| Molecular Weight (MW) | 435.52 | |
| SMILES | CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O | |
| InChIKey | ACWBQPMHZXGDFX-QFIPXVFZSA-N |
Valsartan is a potent and highly selective angiotensin II type 1 (AT1) receptor antagonist. By selectively blocking AT1 receptors, valsartan inhibits angiotensin II-stimulated physiological actions, including vascular smooth muscle contraction and aldosterone secretion. This inhibition attenuates renin-angiotensin-aldosterone system activation, leading to systemic vasodilation, reduced vascular resistance, and effective suppression of blood pressure responses in cardiovascular pathways. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
87 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 87 mg/mL |
| Water | Insoluble |
| DMSO |
87 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 87 mg/mL |
| Water | Insoluble |
| DMSO |
87 mg/mL
(199.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 87 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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