CAS No. 1026785-59-0

Batch: Purity:99.66
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Lomibuvir (VX-222) Chemical Structure
Chemical Structure
Check the Lomibuvir (VX-222) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-(4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid
CAS Number 1026785-59-0
Molecular Formula

C25H35NO4S
Molecular Weight (MW) 445.61
SMILES CC1CCC(CC1)C(=O)N(C2CCC(CC2)O)C3=C(SC(=C3)C#CC(C)(C)C)C(=O)O
InChIKey WPMJNLCLKAKMLA-UHFFFAOYSA-N

Biological Activity

Lomibuvir (VX-222) is a potent and selective non-nucleoside inhibitor targeting the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. By binding to the allosteric site of the NS5B enzyme, Lomibuvir blocks viral RNA synthesis and suppresses HCV replication cascades. Inhibition of this essential viral polymerase disrupts viral genome replication, leading to reduced viral RNA production in hepatitis C infection models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 89 mg/mL (199.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 89 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Gentile I, et al. Expert Opin Investig Drugs. 2014;23(9):1211-23.

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Note: Technical data last updated: Sep 1, 2026.