CAS No. 1173097-76-1

Batch: Purity:99.98
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U0126-EtOH Chemical Structure
Chemical Structure
Check the U0126-EtOH product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile;ethanol
CAS Number 1173097-76-1
Molecular Formula

C18H16N6S2.C2H6O
Molecular Weight (MW) 426.56
SMILES CCO.C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
InChIKey CFQULUVMLGZVAF-OYJDLGDISA-N

Ordering Information

Biological Activity

U0126-EtOH is a highly selective inhibitor of MEK1 (IC50 of and MEK2 (IC50 of. It functionally antagonizes AP-1 transcriptional activity through noncompetitive inhibition of dual-specificity MEK kinases, thereby blocking downstream MAPK/ERK signaling pathway activation. Consequently, this kinase inhibition suppresses anchorage-independent cell growth, blocks cellular proliferation, and induces apoptosis in constitutively active ERK-dependent cancer cell lines. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 85 mg/mL (199.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.