CAS No. 105826-92-4
Batch:
Purity:99.97
Chemical Structure
Check the
Tropisetron HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 105826-92-4 | |
|---|---|---|
| Molecular Formula |
C17H20N2O2.HCl |
|
| Molecular Weight (MW) | 320.81 | |
| SMILES | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43.Cl |
Tropisetron HCl is a potent, selective 5-HT3 receptor antagonist and an α7-nicotinic acetylcholine receptor agonist. By blocking 5-HT3 receptors, it inhibits serotonin-mediated signaling pathways in central and peripheral nervous systems, reducing emetic signaling. Additionally, activation of α7-nicotinic receptors modulates neurotransmitter release and suppresses neuroinflammatory responses. These combined mechanisms contribute to its pharmacological activity in suppressing emesis and modulating neural signaling in cell and animal models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 46 mg/mL |
| Ethanol | Insoluble |
| Water | 64 mg/mL |
| DMSO |
35 mg/mL
(109.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.