CAS No. 35943-35-2

Batch: Purity:99.70
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Triciribine (API-2) Chemical Structure
Chemical Structure
Check the Triciribine (API-2) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2R,3R,4S,5R)-2-(5-amino-7-methyl-2,6,7,9,11-pentazatricyclo[6.3.1.04,12]dodeca-1(12),3,5,8,10-pentaen-2-yl)-5-(hydroxymethyl)oxolane-3,4-diol
CAS Number 35943-35-2
Molecular Formula

C13H16N6O4
Molecular Weight (MW) 320.3
SMILES CN1C2=NC=NC3=C2C(=CN3C4C(C(C(O4)CO)O)O)C(=N1)N
InChIKey HOGVTUZUJGHKPL-HTVVRFAVSA-N

Ordering Information

Biological Activity

Triciribine (API-2) is a synthetic tricyclic nucleoside and selective Akt inhibitor that targets Akt1, Akt2, and Akt3 phosphorylation without directly inhibiting PI3K or PDK1. By suppressing the Akt signaling pathway, triciribine inhibits cell proliferation and selectively induces apoptosis in cancer cells with elevated Akt expression. Downstream, triciribine suppresses tumor growth in nude mouse xenograft models harboring Akt-overexpressing tumors. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 64 mg/mL (199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 16 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.