Numerous clinical trials evaluate topotecan hydrochloride across phases 1 through 4, primarily focusing on malignancies such as retinoblastoma, epithelial ovarian cancer, small cell lung cancer, and acute myeloid leukemia. Sponsored by diverse entities including government bodies, pharmaceutical developers, and academic institutions, these studies encompass recruitment statuses ranging from recruiting and active to completed or terminated.
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05535166 | RECRUITING | Medulloblastoma |
St. Jude Children's Research Hospital |
2022-12-20 | PHASE2 |
| NCT04681417 | RECRUITING | Retinoblastoma |
Institut Curie |
2021-03-25 | PHASE2; PHASE3 |
| NCT07321912 | RECRUITING | Osteosarcoma; Ewing Sarcoma |
Milton S. Hershey Medical Center |
2026-06-05 | PHASE2 |
| NCT05521984 | RECRUITING | Pediatric Brain Tumor; Pediatric Solid Tumor |
Washington University School of Medicine |
2023-04-03 | PHASE1 |
| NCT02813135 | RECRUITING | Pediatric Cancer |
Gustave Roussy, Cancer Campus, Grand Paris |
2016-08-03 | PHASE1; PHASE2 |
| NCT06942039 | RECRUITING | CNS Embryonal Tumor; CNS, Medulloblastoma; Atypical Teratoid Rhabdoid Tumor; Medulloblastoma, Childhood; Medulloblastoma, Group 3; Medulloblastoma, Group 4; Pineoblastoma; Neuroblastoma; Embryonal Tumor With Multilayered Rosettes; Embryonal Tumor With Abundant Neuropil and True Rosettes; Ependymoblastoma; Medulloepithelioma; CNS Embryonal Tumor With Rhabdoid Features; CNS Embryonal Tumor, Nos |
C17 Council |
2025-09-23 | EARLY_PHASE1 |
| NCT07334301 | RECRUITING | Relapsed Neuroblastoma |
University of Birmingham |
2024-11-11 | PHASE1; PHASE2 |
| NCT07194044 | RECRUITING | Metastatic Ewing Sarcoma |
H. Lee Moffitt Cancer Center and Research Institute |
2026-02-05 | PHASE1 |
| NCT03126916 | RECRUITING | Ganglioneuroblastoma; Ganglioneuroblastoma, Nodular; Neuroblastoma |
Children's Oncology Group |
2018-05-14 | PHASE3 |
| NCT07365241 | RECRUITING | Small Cell Lung Cancer |
AbbVie |
2026-07-02 | PHASE3 |
| NCT07141771 | NOT_YET_RECRUITING | SCLC, Extensive Stage |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
2025-12-31 | PHASE1; PHASE2 |
| NCT06172296 | RECRUITING | Ganglioneuroblastoma, Nodular; Neuroblastoma |
National Cancer Institute (NCI) |
2024-04-19 | PHASE3 |
| NCT07286266 | RECRUITING | Ovarian Neoplasms |
GlaxoSmithKline |
2026-06-18 | PHASE3 |
| NCT06679634 | RECRUITING | Retinoblastoma |
Targeted Therapy Technologies, LLC |
2025-02-21 | PHASE2 |
| NCT07708753 | NOT_YET_RECRUITING | Platinum-resistant Ovarian Cancer; Platinum-resistant Primary Peritoneal Cancer; Platinum-resistant Fallopian Tube Cancer |
CSPC Megalith Biopharmaceutical Co.,Ltd. |
2026-07-01 | PHASE3 |
| NCT06801834 | RECRUITING | Extensive Stage Small Cell Lung Cancer (ES-SCLC) |
Gilead Sciences |
2025-04-04 | PHASE3 |
| NCT07437963 | NOT_YET_RECRUITING | Recurrent Ganglioneuroblastoma; Recurrent Neuroblastoma; Refractory Ganglioneuroblastoma; Refractory Neuroblastoma |
National Cancer Institute (NCI) |
2026-10-28 | PHASE1; PHASE2 |
| NCT06528496 | RECRUITING | High-risk Neuroblastoma; Neuroblastoma; Childhood Neuroblastoma |
Memorial Sloan Kettering Cancer Center |
2024-07-22 | PHASE2 |
| NCT06647953 | RECRUITING | Pleuropulmonary Blastoma |
Children's Oncology Group |
2025-03-21 | PHASE3 |
| NCT07545460 | NOT_YET_RECRUITING | Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer |
Sichuan Baili Pharmaceutical Co., Ltd. |
2026-07 | PHASE3 |
| NCT07797153 | NOT_YET_RECRUITING | Recurrent or Metastatic Cervical Cancer |
Jiangsu Alphamab Biopharmaceuticals Co., Ltd |
2026-09 | PHASE3 |
| NCT07218809 | RECRUITING | Epithelial Ovarian Cancer |
AstraZeneca |
2025-12-29 | PHASE3 |
| NCT07213804 | RECRUITING | Ovarian Neoplasms; Fallopian Tube Neoplasms; Peritoneal Neoplasms; Neoplasm Metastasis |
Eli Lilly and Company |
2025-10-22 | PHASE3 |
| NCT07189455 | RECRUITING | Small-cell Lung Cancer |
Suzhou Zelgen Biopharmaceuticals Co.,Ltd |
2025-12-12 | PHASE3 |
| NCT07371663 | RECRUITING | Solid Cancers; NSCLC (Advanced Non-small Cell Lung Cancer); Gastric (Stomach) Cancer; Endometrial Cancer; Malignant Melanoma |
Beijing Tide Pharmaceutical Co., Ltd |
2025-12-03 | PHASE1; PHASE2 |
| NCT07076095 | NOT_YET_RECRUITING | Small Cell Lung Cancer |
SUNHO（China）BioPharmaceutical CO., Ltd. |
2025-08-01 | PHASE2 |
| NCT05800587 | RECRUITING | Lung Cancer; Small-cell Lung Cancer; Non Small Cell Lung Cancer |
Fox Chase Cancer Center |
2023-02-22 | PHASE2 |
| NCT06459180 | ACTIVE_NOT_RECRUITING | Cervical Cancer |
Merck Sharp & Dohme LLC |
2024-07-24 | PHASE3 |
| NCT06128837 | RECRUITING | Relapsed Small Cell Lung Cancer |
Luye Pharma Group Ltd. |
2024-03-03 | PHASE3 |
| NCT06161025 | RECRUITING | Solid Cancer |
Daiichi Sankyo |
2024-02-27 | PHASE2; PHASE3 |
| NCT06203210 | RECRUITING | Small Cell Lung Cancer |
Daiichi Sankyo |
2024-05-21 | PHASE3 |
| NCT06666712 | RECRUITING | Brain Tumor, Recurrent; Malignant Glioma (WHO Grade III or IV); IDH1/IDH2 Mutation |
Jeffrey N. Bruce |
2026-06-12 | PHASE1 |
| NCT06496048 | RECRUITING | Relapsed Small Cell Lung Cancer |
Luye Pharma Group Ltd. |
2024-09-14 | PHASE3 |
| NCT06612151 | ACTIVE_NOT_RECRUITING | Small Cell Lung Cancer |
MediLink Therapeutics (Suzhou) Co., Ltd. |
2024-12-17 | PHASE3 |
| NCT06425419 | NOT_YET_RECRUITING | Proliferative Vitreoretinopathy; Proliferative Vitreo-Retinopathy; Rhegmatogenous Retinal Detachment |
Massachusetts Eye and Ear Infirmary |
2026-09-01 | PHASE1 |
| NCT07418749 | RECRUITING | Recurrent Cervical Cancer; Metastatic Cervical Cancer |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
2026-03-30 | PHASE3 |
| NCT07106528 | NOT_YET_RECRUITING | Extensive-stage Small Cell Lung Cancer (ES-SCLC); Extensive-stage Small Cell Lung Cancer (SCLC); Small Cell Lung Cancer ( SCLC ) |
Peking Union Medical College Hospital |
2025-08 | PHASE2; PHASE3 |
| NCT02354547 | SUSPENDED | Neoplasm |
SynerGene Therapeutics, Inc. |
2014-12 | PHASE1 |
| NCT05652686 | RECRUITING | Small Cell Lung Cancer (SCLC); Large Cell Neuroendocrine Cancer (LCNEC); Neuroendocrine Prostate Cancer (NEPC); Gastroenteropancreatic Neuroendocrine Carcinoma (GEP-NEC); Neuroendocrine Carcinomas (NEC); Extrapulmonary Neuroendocrine Carcinoma (EP-NEC) |
Phanes Therapeutics |
2023-09-05 | PHASE1; PHASE2 |
| NCT06581380 | NOT_YET_RECRUITING | Small Cell Lung Cancer |
JenKem Technology Co., Ltd. |
2024-09-16 | PHASE3 |
| NCT07099898 | RECRUITING | Neoplasms, Lung |
GlaxoSmithKline |
2025-08-11 | PHASE3 |
| NCT05874401 | RECRUITING | Extensive-stage Small-cell Lung Cancer |
Pharmacosmos A/S |
2023-10-18 | PHASE4 |
| NCT07604766 | RECRUITING | Platinum-resistant Ovarian Cancer |
Genmab |
2026-06-26 | PHASE3 |
| NCT05303727 | NOT_YET_RECRUITING | Neuroblastoma |
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University |
2022-08 | PHASE2 |
| NCT04322318 | RECRUITING | Anaplastic Kidney Wilms Tumor; Recurrent Kidney Wilms Tumor; Stage II Kidney Wilms Tumor; Stage III Kidney Wilms Tumor; Stage IV Kidney Wilms Tumor |
Children's Oncology Group |
2020-10-19 | PHASE2 |
| NCT04947501 | ACTIVE_NOT_RECRUITING | Neuroblastoma; Pediatric Cancer |
Memorial Sloan Kettering Cancer Center |
2021-06-22 | EARLY_PHASE1 |
| NCT06449209 | ACTIVE_NOT_RECRUITING | Extensive-stage Small-cell Lung Cancer; Small-cell Lung Cancer |
BioNTech SE |
2024-08-05 | PHASE2 |
| NCT06994195 | RECRUITING | Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer |
Sichuan Baili Pharmaceutical Co., Ltd. |
2025-08-04 | PHASE3 |
| NCT06930755 | RECRUITING | Ovarian Cancer |
Nerviano Medical Sciences |
2026-05-13 | PHASE1 |
| NCT06828354 | RECRUITING | Ovarian Cancer |
Jiangsu HengRui Medicine Co., Ltd. |
2025-03-13 | PHASE3 |
| NCT06954246 | RECRUITING | Small Cell Lung Cancer Extensive Stage |
Qilu Pharmaceutical Co., Ltd. |
2025-06-04 | PHASE3 |
| NCT06818721 | NOT_YET_RECRUITING | Retinal Detachment Rhegmatogenous; Proliferative Vitreoretinopathy |
Unity Health Toronto |
2025-03 | PHASE2 |
| NCT05101551 | RECRUITING | Acute Myeloid Leukemia |
Norman J. Lacayo |
2023-02-23 | PHASE1 |
| NCT05990738 | ACTIVE_NOT_RECRUITING | Small Cell Lung Carcinoma (SCLC) |
Boehringer Ingelheim |
2024-02-14 | PHASE1 |
| NCT06855069 | RECRUITING | Ovarian Cancer |
Hansoh BioMedical R&D Company |
2025-03-13 | PHASE3 |
| NCT06619236 | ACTIVE_NOT_RECRUITING | Platinum-resistant Ovarian Cancer |
Genmab |
2025-02-07 | PHASE3 |
| NCT06616532 | ACTIVE_NOT_RECRUITING | SCLC |
Biotheus Inc. |
2024-11-13 | PHASE3 |
| NCT06751485 | NOT_YET_RECRUITING | Ovarian Cancer; Primary Peritoneal; Fallopian Tube Cancers |
Jiangsu Alphamab Biopharmaceuticals Co., Ltd |
2025-01-15 | PHASE3 |
| NCT04047251 | ACTIVE_NOT_RECRUITING | Advanced Solid Tumors; Merkel Cell Carcinoma |
Fujifilm Pharmaceuticals U.S.A., Inc. |
2019-11-14 | PHASE1 |
| NCT06500026 | ACTIVE_NOT_RECRUITING | Small Cell Lung Cancer |
Sichuan Baili Pharmaceutical Co., Ltd. |
2024-08-07 | PHASE3 |
| NCT02298348 | ACTIVE_NOT_RECRUITING | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2015-10-08 | PHASE1 |
| NCT06498479 | RECRUITING | Small Cell Lung Cancer |
Hansoh BioMedical R&D Company |
2024-07-04 | PHASE3 |
| NCT07145333 | ACTIVE_NOT_RECRUITING | SCLC |
Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair |
2025-08-12 | PHASE2; PHASE3 |
| NCT06548763 | NOT_YET_RECRUITING | Endometrial Cancer |
Fudan University |
2024-11-30 | PHASE2 |
| NCT06394492 | RECRUITING | Ovarian Cancer |
Suzhou Suncadia Biopharmaceuticals Co., Ltd. |
2024-05-10 | PHASE3 |
| NCT05153239 | COMPLETED | Relapsed Small Cell Lung Cancer |
PharmaMar |
2022-07-22 | PHASE3 |
| NCT05353439 | ACTIVE_NOT_RECRUITING | Extensive Stage Lung Small Cell Carcinoma; Limited Stage Lung Small Cell Carcinoma; Platinum-Resistant Lung Small Cell Carcinoma; Platinum-Sensitive Lung Small Cell Carcinoma; Recurrent Extensive Stage Lung Small Cell Carcinoma; Recurrent Lung Small Cell Carcinoma |
National Cancer Institute (NCI) |
2022-07-27 | PHASE1 |
| NCT05736952 | WITHDRAWN | Platinum-resistant Ovarian Cancer |
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine |
2023-03-01 | PHASE2 |
| NCT05523869 | RECRUITING | Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment |
Unity Health Toronto |
2023-02-23 | PHASE2 |
| NCT06972602 | RECRUITING | Retinoblastoma; Retinoblastoma, Recurrent |
Eye & ENT Hospital of Fudan University |
2025-04-01 | EARLY_PHASE1 |
| NCT02114229 | ACTIVE_NOT_RECRUITING | Malignant Rhabdoid Tumor; Atypical Teratoid Rhabdoid Tumor |
St. Jude Children's Research Hospital |
2014-05-14 | PHASE2 |
| NCT03600649 | UNKNOWN | Ewing Sarcoma; Myxoid Liposarcoma; Sarcoma,Soft Tissue; Desmoplastic Small Round Cell Tumor; Extraskeletal Myxoid Chondrosarcoma; Angiomatoid Fibrous Histiocytoma; Clear Cell Sarcoma; Primary Pulmonary Myxoid Sarcoma; Myoepithelial Tumor; Sclerosing Epithelioid Fibrosarcoma; Fibromyxoid Tumor |
Salarius Pharmaceuticals, LLC |
2018-06-04 | PHASE1 |
| NCT05870748 | TERMINATED | Ovarian Cancer; Epithelial Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer; Platinum-resistant Ovarian Cancer |
Sutro Biopharma, Inc. |
2023-07-12 | PHASE2; PHASE3 |
| NCT04239092 | TERMINATED | Refractory Cancer; Refractory Neoplasm; Cancer Pediatric; Refractory Tumor; Pediatric Cancer; Pediatric Brain Tumor; Neuroblastoma; Neuroblastoma Recurrent; Pediatric Lymphoma; Pediatric Meningioma; Diffuse Intrinsic Pontine Glioma |
Actuate Therapeutics Inc. |
2020-06-05 | PHASE1 |
| NCT05429502 | TERMINATED | Neuroblastoma |
Novartis Pharmaceuticals |
2022-12-27 | PHASE1 |
| NCT04514497 | ACTIVE_NOT_RECRUITING | Metastatic Lung Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Neuroendocrine Carcinoma; Metastatic Pancreatic Adenocarcinoma; Stage III Lung Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Unresectable Lung Small Cell Carcinoma; Unresectable Malignant Solid Neoplasm; Unresectable Neuroendocrine Carcinoma; Unresectable Pancreatic Adenocarcinoma |
National Cancer Institute (NCI) |
2021-10-20 | PHASE1 |
| NCT05740566 | ACTIVE_NOT_RECRUITING | Small Cell Lung Cancer (SCLC) |
Amgen |
2023-05-31 | PHASE3 |
| NCT05092360 | TERMINATED | Platinum-resistant Ovarian Cancer; Fallopian Tube Cancer; Primary Peritoneal Cancer |
Mural Oncology, Inc |
2022-01-10 | PHASE3 |
| NCT04679064 | UNKNOWN | Ovarian Cancer |
Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
2020-12-01 | PHASE3 |
| NCT04799002 | RECRUITING | Retinoblastoma; Chemotherapy Effect |
Sun Yat-sen University |
2021-03-11 | PHASE3 |
| NCT04428879 | COMPLETED | Retinoblastoma |
The Hospital for Sick Children |
2020-06-16 | PHASE1 |
| NCT04156347 | UNKNOWN | Retinoblastoma |
Targeted Therapy Technologies, LLC |
2021-06-16 | PHASE1 |
| NCT02584478 | UNKNOWN | Endometrial Carcinoma; Ovarian Carcinoma; Fallopian Tube Carcinoma; Primary Peritoneal Carcinoma; Cervical Carcinoma |
Advenchen Laboratories, LLC |
2015-12 | PHASE3 |
| NCT02419495 | TERMINATED | Advanced Malignant Solid Neoplasm; Clinical Stage III Cutaneous Melanoma AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Fallopian Tube Carcinoma; Metastatic Lung Non-Small Cell Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Melanoma; Metastatic Renal Cell Carcinoma; Ovarian Carcinoma; Pathologic Stage III Cutaneous Melanoma AJCC v8; Pathologic Stage IIIA Cutaneous Melanoma AJCC v8; Pathologic Stage IIIB Cutaneous Melanoma AJCC v8; Pathologic Stage IIIC Cutaneous Melanoma AJCC v8; Pathologic Stage IIID Cutaneous Melanoma AJCC v8; Pathologic Stage IV Cutaneous Melanoma AJCC v8; Primary Peritoneal Carcinoma; Stage III Lung Cancer AJCC v8; Stage III Renal Cell Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IV Renal Cell Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8; Triple-Negative Breast Carcinoma; Unresectable Lung Non-Small Cell Carcinoma; Unresectable Melanoma; Unresectable Renal Cell Carcinoma |
M.D. Anderson Cancer Center |
2015-06-26 | PHASE1 |
| NCT03709680 | ACTIVE_NOT_RECRUITING | Ewing Sarcoma; Solid Tumors; Rhabdoid Tumor; Rhabdomyosarcoma; Neuroblastoma; Medulloblastoma; Diffuse Intrinsic Pontine Glioma |
Pfizer |
2019-05-24 | PHASE2 |
| NCT03107988 | COMPLETED | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2017-09-05 | PHASE1 |
| NCT04994977 | TERMINATED | Atypical Choroid Plexus Papilloma; Choroid Plexus Carcinoma |
Weill Medical College of Cornell University |
2023-05-04 | PHASE1 |
| NCT05613088 | COMPLETED | Neoplasms, Ovarian |
Bristol-Myers Squibb |
2023-02-01 | PHASE2 |
| NCT04029688 | TERMINATED | Acute Myeloid Leukemia (AML); Acute Lymphoblastic Leukemia (ALL); Neuroblastoma; Solid Tumors |
Hoffmann-La Roche |
2020-01-27 | PHASE1; PHASE2 |
| NCT02030964 | COMPLETED | Neuroblastoma |
New Approaches to Neuroblastoma Therapy Consortium |
2014-01-16 | PHASE1 |
| NCT04908787 | COMPLETED | Ovarian Cancer |
Jiangsu Simcere Pharmaceutical Co., Ltd. |
2021-06-11 | PHASE3 |
| NCT00657878 | UNKNOWN | Ovarian Cancer |
National Cancer Institute, Naples |
2008-11 | PHASE3 |
| NCT03165292 | TERMINATED | Very High Risk Neuroblastoma |
Gustave Roussy, Cancer Campus, Grand Paris |
2018-10-01 | PHASE2 |
| NCT04697628 | COMPLETED | Cervical Cancer |
Seagen, a wholly owned subsidiary of Pfizer |
2021-02-22 | PHASE3 |
| NCT04768296 | COMPLETED | Small-cell Lung Cancer |
EMD Serono Research & Development Institute, Inc. |
2021-03-29 | PHASE2 |
| NCT05246111 | COMPLETED | Advanced Solid Tumor |
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany |
2022-02-15 | PHASE1 |
| NCT02502266 | ACTIVE_NOT_RECRUITING | Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Endometrioid Adenocarcinoma; Fallopian Tube Serous Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Fallopian Tube Undifferentiated Carcinoma; Ovarian Clear Cell Adenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Adenocarcinoma; Ovarian Transitional Cell Carcinoma; Ovarian Undifferentiated Carcinoma; Primary Peritoneal Serous Adenocarcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma |
National Cancer Institute (NCI) |
2016-05-03 | PHASE2; PHASE3 |
| NCT03289910 | ACTIVE_NOT_RECRUITING | Acute Myeloid Leukemia; Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome; Atypical Chronic Myeloid Leukemia; Chronic Myelomonocytic Leukemia; Essential Thrombocythemia; Myelodysplastic/Myeloproliferative Neoplasm; Myelofibrosis; Polycythemia Vera; Recurrent Acute Myeloid Leukemia; Refractory Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2018-09-24 | PHASE2 |
| NCT03927274 | TERMINATED | Glioma of Brain |
H. Lee Moffitt Cancer Center and Research Institute |
2019-06-20 | EARLY_PHASE1 |
| NCT04455139 | TERMINATED | Eye Cancer, Retinoblastoma |
Prof. Beck Popovic Maja |
2021-11-15 | PHASE2 |
| NCT02312245 | COMPLETED | Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma |
Mayo Clinic |
2015-07-21 | PHASE2 |
| NCT01783535 | ACTIVE_NOT_RECRUITING | Retinoblastoma |
St. Jude Children's Research Hospital |
2013-06-19 | PHASE2 |
| NCT05295589 | WITHDRAWN | Platinum-Refractory Fallopian Tube Carcinoma; Platinum-Refractory Ovarian Carcinoma; Platinum-Refractory Primary Peritoneal Carcinoma; Recurrent Fallopian Tube Endometrioid Adenocarcinoma; Recurrent Fallopian Tube High Grade Serous Adenocarcinoma; Recurrent Ovarian Endometrioid Adenocarcinoma; Recurrent Ovarian High Grade Serous Adenocarcinoma; Recurrent Platinum-Resistant Fallopian Tube Carcinoma; Recurrent Platinum-Resistant Ovarian Carcinoma; Recurrent Platinum-Resistant Primary Peritoneal Carcinoma; Recurrent Primary Peritoneal Endometrioid Adenocarcinoma; Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma |
National Cancer Institute (NCI) |
2022-06-30 | PHASE2 |
| NCT04209855 | COMPLETED | Epithelial Ovarian Cancer; Peritoneal Cancer; Fallopian Tube Cancer |
AbbVie |
2019-12-31 | PHASE3 |
| NCT03475121 | COMPLETED | Unilateral Retinoblastoma |
Hospital JP Garrahan |
2018-01-01 | PHASE3 |
| NCT04739800 | ACTIVE_NOT_RECRUITING | Fallopian Tube Mucinous Adenocarcinoma; Ovarian Seromucinous Carcinoma; Platinum-Refractory Fallopian Tube Carcinoma; Platinum-Refractory Ovarian Carcinoma; Platinum-Refractory Primary Peritoneal Carcinoma; Recurrent Fallopian Tube Clear Cell Adenocarcinoma; Recurrent Fallopian Tube Endometrioid Adenocarcinoma; Recurrent Fallopian Tube High Grade Serous Adenocarcinoma; Recurrent Fallopian Tube Mucinous Adenocarcinoma; Recurrent Fallopian Tube Transitional Cell Carcinoma; Recurrent Fallopian Tube Undifferentiated Carcinoma; Recurrent Low Grade Fallopian Tube Serous Adenocarcinoma; Recurrent Ovarian Clear Cell Adenocarcinoma; Recurrent Ovarian Endometrioid Adenocarcinoma; Recurrent Ovarian High Grade Serous Adenocarcinoma; Recurrent Ovarian Low Grade Serous Adenocarcinoma; Recurrent Ovarian Mucinous Adenocarcinoma; Recurrent Ovarian Seromucinous Carcinoma; Recurrent Ovarian Transitional Cell Carcinoma; Recurrent Ovarian Undifferentiated Carcinoma; Recurrent Platinum-Resistant Fallopian Tube Carcinoma; Recurrent Platinum-Resistant Ovarian Carcinoma; Recurrent Platinum-Resistant Primary Peritoneal Carcinoma; Recurrent Primary Peritoneal Clear Cell Adenocarcinoma; Recurrent Primary Peritoneal Endometrioid Adenocarcinoma; Recurrent Primary Peritoneal High Grade Serous Adenocarcinoma; Recurrent Primary Peritoneal Low Grade Serous Adenocarcinoma; Recurrent Primary Peritoneal Transitional Cell Carcinoma; Recurrent Primary Peritoneal Undifferentiated Carcinoma; Refractory Fallopian Tube Clear Cell Adenocarcinoma; Refractory Fallopian Tube Endometrioid Adenocarcinoma; Refractory Fallopian Tube High Grade Serous Adenocarcinoma; Refractory Fallopian Tube Mucinous Adenocarcinoma; Refractory Fallopian Tube Transitional Cell Carcinoma; Refractory Fallopian Tube Undifferentiated Carcinoma; Refractory Low Grade Fallopian Tube Serous Adenocarcinoma; Refractory Ovarian Clear Cell Adenocarcinoma; Refractory Ovarian Endometrioid Adenocarcinoma; Refractory Ovarian High Grade Serous Adenocarcinoma; Refractory Ovarian Low Grade Serous Adenocarcinoma; Refractory Ovarian Mucinous Adenocarcinoma; Refractory Ovarian Seromucinous Carcinoma; Refractory Ovarian Transitional Cell Carcinoma; Refractory Ovarian Undifferentiated Carcinoma; Refractory Primary Peritoneal Clear Cell Adenocarcinoma; Refractory Primary Peritoneal Endometrioid Adenocarcinoma; Refractory Primary Peritoneal High Grade Serous Adenocarcinoma; Refractory Primary Peritoneal Low Grade Serous Adenocarcinoma; Refractory Primary Peritoneal Transitional Cell Carcinoma; Refractory Primary Peritoneal Undifferentiated Carcinoma |
National Cancer Institute (NCI) |
2021-06-10 | PHASE2 |
| NCT03896503 | ACTIVE_NOT_RECRUITING | Extensive Stage Lung Small Cell Carcinoma; Extrapulmonary Small Cell Neuroendocrine Carcinoma; Limited Stage Lung Small Cell Carcinoma; Platinum-Resistant Lung Small Cell Carcinoma; Platinum-Sensitive Lung Small Cell Carcinoma; Recurrent Lung Small Cell Carcinoma |
National Cancer Institute (NCI) |
2019-12-30 | PHASE2 |
| NCT04661852 | COMPLETED | Relapsed Ewing Sarcoma; Refractory Ewing Sarcoma; Relapsed Osteosarcoma; Refractory Osteosarcoma |
Dana-Farber Cancer Institute |
2020-12-23 | PHASE1 |
| NCT04022876 | TERMINATED | Non Small Cell Lung Cancer; Small-cell Lung Cancer |
Aileron Therapeutics, Inc. |
2019-09-03 | PHASE1 |
| NCT02303028 | COMPLETED | Solid Tumors |
The Hospital for Sick Children |
2015-03 | PHASE1; PHASE2 |
| NCT03554473 | COMPLETED | Carcinoma, Small Cell; Lung Cancer; Small Cell Lung Cancer |
National Cancer Institute (NCI) |
2018-09-11 | PHASE1; PHASE2 |
| NCT04106219 | ACTIVE_NOT_RECRUITING | Neuroblastoma |
Eli Lilly and Company |
2020-06-11 | PHASE1 |
| NCT03088813 | COMPLETED | Small Cell Lung Cancer |
Ipsen |
2018-04-25 | PHASE3 |
| NCT02364713 | TERMINATED | Fallopian Tube Carcinosarcoma; Fallopian Tube Clear Cell Adenocarcinoma; Fallopian Tube Endometrioid Adenocarcinoma; Fallopian Tube Mucinous Adenocarcinoma; Fallopian Tube Serous Adenocarcinoma; Fallopian Tube Transitional Cell Carcinoma; Fallopian Tube Undifferentiated Carcinoma; Ovarian Carcinosarcoma; Ovarian Clear Cell Adenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Adenocarcinoma; Ovarian Seromucinous Carcinoma; Ovarian Serous Adenocarcinoma; Ovarian Transitional Cell Carcinoma; Ovarian Undifferentiated Carcinoma; Platinum-Resistant Fallopian Tube Carcinoma; Platinum-Resistant Ovarian Carcinoma; Platinum-Resistant Primary Peritoneal Carcinoma; Primary Peritoneal Carcinosarcoma; Primary Peritoneal Clear Cell Adenocarcinoma; Primary Peritoneal Endometrioid Adenocarcinoma; Primary Peritoneal Serous Adenocarcinoma; Primary Peritoneal Transitional Cell Carcinoma; Primary Peritoneal Undifferentiated Carcinoma; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma |
Mayo Clinic |
2015-03-13 | PHASE2 |
| NCT05083000 | UNKNOWN | COVID-19 Respiratory Infection |
National University Hospital, Singapore |
2021-08-16 | PHASE1 |
| NCT03786783 | COMPLETED | Ganglioneuroblastoma; High Risk Neuroblastoma |
National Cancer Institute (NCI) |
2019-03-04 | PHASE2 |
| NCT04902885 | COMPLETED | Extensive-stage Small-cell Lung Cancer |
Jiangsu Simcere Pharmaceutical Co., Ltd. |
2021-05-25 | PHASE3 |
| NCT01143779 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2010-06 | PHASE1 |
| NCT02866006 | COMPLETED | Uterine Cervical Neoplasms |
Cellid Co., Ltd. |
2016-10 | PHASE1; PHASE2 |
| NCT04455139 | Terminated | Eye Cancer Retinoblastoma |
Prof. Beck Popovic Maja|University of Lausanne Hospitals |
2021-11-15 | Phase 2 |
| NCT04943627 | WITHDRAWN | Advanced Cancer; Metastatic Cervical Cancer |
Agenus Inc. |
2021-08-02 | PHASE3 |
| NCT01857934 | COMPLETED | Neuroblastoma |
St. Jude Children's Research Hospital |
2013-07-05 | PHASE2 |
| NCT03154996 | COMPLETED | Gliomas |
Columbia University |
2018-01-18 | PHASE1 |
| NCT02308527 | COMPLETED | Neuroblastoma |
University of Birmingham |
2013-07 | PHASE2 |
| NCT05083000 | Unknown status | COVID-19 Respiratory Infection |
National University Hospital Singapore|Christian Medical College Vellore India |
2021-08-16 | Phase 1 |
| NCT04073550 | UNKNOWN | Small Cell Lung Cancer |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
2019-10-31 | PHASE3 |
| NCT04213937 | UNKNOWN | Extensive Stage Small Cell Lung Cancer |
Cancer Institute and Hospital, Chinese Academy of Medical Sciences |
2020-01-31 | PHASE2 |
| NCT02649673 | TERMINATED | Small Cell Lung Cancer; Ovarian Cancer |
SCRI Development Innovations, LLC |
2016-03-23 | PHASE1 |
| NCT02822157 | UNKNOWN | Ovarian Epithelial Cancer |
Universitaire Ziekenhuizen KU Leuven |
2016-08 | PHASE2 |
| NCT04156347 | Active not recruiting | Retinoblastoma |
Targeted Therapy Technologies LLC |
2021-06-16 | Phase 1 |
| NCT03227016 | UNKNOWN | Small Cell Lung Cancer SCLC |
Central European Society for Anticancer Drug Research |
2016-10 | PHASE1 |
| NCT02487095 | COMPLETED | Carcinoma, Non-Small -Cell Lung; Ovarian Neoplasms; Small Cell Lung Carcinoma; Uterine Cervical Neoplasms; Carcinoma, Neuroendocrine; Extrapulmonary Small Cell Cancer |
National Cancer Institute (NCI) |
2015-07-30 | PHASE1; PHASE2 |
| NCT03987685 | COMPLETED | Solid Tumor |
Athenex, Inc. |
2018-07-19 | PHASE1 |
| NCT00317772 | COMPLETED | Ovarian Cancer; Peritoneal Neoplasms; Fallopian Tube Cancer |
M.D. Anderson Cancer Center |
2004-09-02 | PHASE1; PHASE2 |
| NCT04428879 | Recruiting | Retinoblastoma |
The Hospital for Sick Children |
2020-06-16 | Phase 1 |
| NCT00601003 | COMPLETED | Neuroblastoma; Medulloblastoma |
Giselle Sholler |
2008-01-14 | PHASE2 |
| NCT01231906 | COMPLETED | Localized Extraskeletal Ewing Sarcoma; Peripheral Primitive Neuroectodermal Tumor of Bone; Peripheral Primitive Neuroectodermal Tumor of Soft Tissues |
Children's Oncology Group |
2010-11-24 | PHASE3 |
| NCT02866370 | UNKNOWN | Ovarian Clear Cell Carcinoma; Endometrial Clear Cell Carcinoma |
NHS Greater Glasgow and Clyde |
2015-04 | PHASE2 |
| NCT02566993 | COMPLETED | Small-cell Lung Cancer |
PharmaMar |
2016-08-30 | PHASE3 |
| NCT03061812 | COMPLETED | Small Cell Lung Cancer |
AbbVie |
2017-04-11 | PHASE3 |
| NCT03098030 | COMPLETED | Small Cell Lung Cancer |
United Therapeutics |
2017-06-01 | PHASE2; PHASE3 |
| NCT03763123 | UNKNOWN | Ovarian Cancer |
Jiangsu Simcere Pharmaceutical Co., Ltd. |
2018-04-24 | PHASE1 |
| NCT02684071 | TERMINATED | Recurrent Childhood Medulloblastoma; Recurrent Childhood Ependymoma; Childhood Atypical Teratoid/Rhabdoid Tumor; Embryonal Tumor With Abundant Neuropil and True Rosettes; Metastatic Malignant Neoplasm to the Leptomeninges |
Nicklaus Children's Hospital f/k/a Miami Children's Hospital |
2016-02 | PHASE2 |
| NCT02390843 | COMPLETED | Retinoblastoma; Clear Cell Sarcoma; Renal Cell Carcinoma; Rhabdoid Tumor; Wilms Tumor; Hepatoblastoma; Neuroblastoma; Germ Cell Tumors; Ewings Sarcoma; Non-rhabdomyosarcoma Soft Tissue Sarcoma; Osteosarcoma; Rhabdomyosarcoma |
Emory University |
2015-02 | PHASE1 |
| NCT01931098 | COMPLETED | Glioblastoma; Glioblastoma Multiforme; Gliosarcoma; Brain Neoplasms; Central Nervous System Neoplasms |
National Cancer Institute (NCI) |
2015-12-10 | PHASE2 |
| NCT02348398 | WITHDRAWN | Cervical Cancer |
M.D. Anderson Cancer Center |
2016-08 | PHASE2 |
| NCT02963090 | TERMINATED | Small Cell Lung Cancer |
Alliance Foundation Trials, LLC. |
2017-05-20 | PHASE2 |
| NCT02030184 | WITHDRAWN | Small Cell Lung Cancer (SCLC); Neuroendocrine (NE) Tumors; Large Cell Neuroendocrine (NE) Tumors |
University of Maryland, Baltimore |
2017-06 | PHASE1; PHASE2 |
| NCT02101788 | COMPLETED | Borderline Ovarian Serous Tumor; Micropapillary Serous Carcinoma; Ovarian Serous Adenocarcinoma; Primary Peritoneal Serous Adenocarcinoma; Recurrent Ovarian Low Grade Serous Adenocarcinoma; Recurrent Primary Peritoneal Serous Adenocarcinoma |
National Cancer Institute (NCI) |
2014-04-11 | PHASE2; PHASE3 |
| NCT02980809 | UNKNOWN | Small Cell Lung Cancer |
First Hospitals affiliated to the China PLA General Hospital |
2017-03 | PHASE2 |
| NCT02786719 | COMPLETED | Neuroblastoma |
Baylor College of Medicine |
2016-06 | |
| NCT01012817 | ACTIVE_NOT_RECRUITING | Metastatic Malignant Solid Neoplasm; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma; Unresectable Solid Neoplasm |
National Cancer Institute (NCI) |
2009-11-03 | PHASE1; PHASE2 |
| NCT00877110 | COMPLETED | Neuroblastoma; Bone Marrow, Sympathetic Nervous System |
Memorial Sloan Kettering Cancer Center |
2009-04-02 | PHASE1 |
| NCT02631876 | COMPLETED | Epithelial Ovarian Cancer; Primary Peritoneal Carcinoma; Fallopian Tube Cancer; Ovarian Cancer |
ImmunoGen, Inc. |
2016-03-02 | PHASE3 |
| NCT01606878 | COMPLETED | Childhood Solid Neoplasm; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Neuroblastoma |
Children's Oncology Group |
2013-04-29 | PHASE1 |
| NCT02903004 | COMPLETED | Ovarian Neoplasms |
Fondazione Policlinico Universitario Agostino Gemelli IRCCS |
2016-04-11 | PHASE3 |
| NCT02500459 | TERMINATED | Brain Tumor; High Grade Glioma |
Michael Vogelbaum, MD, PhD |
2015-07-06 | EARLY_PHASE1 |
| NCT03193463 | WITHDRAWN | Glioma |
Michael Vogelbaum, MD, PhD |
2017-11-03 | EARLY_PHASE1 |
| NCT01492673 | COMPLETED | Neuroblastoma; Sarcoma |
Memorial Sloan Kettering Cancer Center |
2011-12 | PHASE2 |
| NCT02421588 | COMPLETED | Ovarian Cancer |
PharmaMar |
2015-05 | PHASE3 |
| NCT02514447 | COMPLETED | Small Cell Lung Cancer |
G1 Therapeutics, Inc. |
2015-10-05 | PHASE1; PHASE2 |
| NCT03059667 | COMPLETED | Small Cell Lung Cancer; Small Cell Lung Cancer Limited Stage; Small Cell Lung Cancer Extensive Stage |
Intergroupe Francophone de Cancerologie Thoracique |
2017-03-13 | PHASE2 |
| NCT02481830 | COMPLETED | Lung Cancer |
Bristol-Myers Squibb |
2015-09-14 | PHASE3 |
| NCT02357810 | COMPLETED | Adult Liposarcoma; Metastatic Liposarcoma; Metastatic Osteosarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Liposarcoma; Recurrent Osteosarcoma; Stage IV Adult Soft Tissue Sarcoma |
Northwestern University |
2015-03-21 | PHASE2 |
| NCT01654965 | COMPLETED | Adult Solid Neoplasm |
National Cancer Institute (NCI) |
2012-07-24 | PHASE1 |
| NCT01795430 | WITHDRAWN | Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor |
City of Hope Medical Center |
2013-07 | |
| NCT00856037 | COMPLETED | Recurrent Small Cell Lung Carcinoma |
University of Nebraska |
2009-02-02 | PHASE1 |
| NCT01497873 | COMPLETED | Small Cell Lung Cancer |
Chong Kun Dang Pharmaceutical |
2010-09 | PHASE2 |
| NCT02738346 | UNKNOWN | Small Cell Lung Cancer |
University Hospital, Angers |
2013-07 | PHASE3 |
| NCT02200757 | COMPLETED | Metastatic Small Cell Lung Cancer |
ImmunityBio, Inc. |
2015-04-20 | PHASE2 |
| NCT01600573 | UNKNOWN | Ovarian Cancer |
JSehouli |
2012-05 | PHASE1; PHASE2 |
| NCT00526318 | UNKNOWN | Neuroblastoma |
German Society for Pediatric Oncology and Hematology GPOH gGmbH |
2007-01 | |
| NCT00588991 | COMPLETED | Adult Acute Megakaryoblastic Leukemia; Adult Acute Monoblastic Leukemia; Adult Acute Monocytic Leukemia; Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With Maturation; Adult Acute Myeloid Leukemia With Minimal Differentiation; Adult Acute Myeloid Leukemia With t(16;16)(p13.1;q22); CBFB-MYH11; Adult Acute Myeloid Leukemia With t(8;21); (q22; q22.1); RUNX1-RUNX1T1; Adult Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3); MLLT3-KMT2A; Adult Acute Myeloid Leukemia Without Maturation; Adult Acute Myelomonocytic Leukemia; Adult Erythroleukemia; Adult Pure Erythroid Leukemia; Chronic Myeloid Leukemia, Philadelphia Chromosome Negative, BCR-ABL1 Positive; Chronic Myelomonocytic Leukemia; De Novo Myelodysplastic Syndrome; Essential Thrombocythemia; Hematopoietic and Lymphoid Cell Neoplasm; Myelodysplastic Syndrome; Polycythemia Vera; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Secondary Myelodysplastic Syndrome |
National Cancer Institute (NCI) |
2008-02-04 | PHASE1 |
| NCT01175356 | COMPLETED | Ganglioneuroblastoma; Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma |
Children's Oncology Group |
2011-12-21 | PHASE1 |
| NCT01593228 | COMPLETED | Solid Tumors |
Sanofi |
2012-05 | PHASE3 |
| NCT01670175 | COMPLETED | Malignant Solid Tumor; Childhood Solid Tumor |
University of California, San Francisco |
2012-08 | PHASE1 |
| NCT01696032 | COMPLETED | Ovarian Cancer |
Astex Pharmaceuticals, Inc. |
2012-09 | PHASE2 |
| NCT02107378 | TERMINATED | Epithelial Ovarian Carcinoma |
SOTIO a.s. |
2014-01 | PHASE2 |
| NCT02569957 | TERMINATED | Malignant Ovarian Endometrioid Tumor; Malignant Ovarian Serous Tumor; Recurrent Fallopian Tube Carcinoma; Recurrent Ovarian Carcinoma; Recurrent Primary Peritoneal Carcinoma |
Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University |
2015-10-02 | PHASE2 |
| NCT01417806 | UNKNOWN | Small Cell Lung Cancer |
South Florida Veterans Affairs Foundation for Research and Education |
2011-07 | PHASE2 |
| NCT00960739 | COMPLETED | Neuroblastoma |
Centre Oscar Lambret |
2008-11 | PHASE2 |
| NCT01803269 | TERMINATED | Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer |
University of Chicago |
2013-01-16 | PHASE2 |
| NCT01683149 | COMPLETED | Solid Tumor |
H. Lee Moffitt Cancer Center and Research Institute |
2013-01 | PHASE1 |
| NCT01266447 | COMPLETED | Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Small Cell Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Carcinoma; Stage III Cervical Cancer; Stage IVA Cervical Cancer; Stage IVB Cervical Cancer |
National Cancer Institute (NCI) |
2011-02 | PHASE2 |
| NCT02100007 | TERMINATED | Solid Tumors |
MEI Pharma, Inc. |
2014-04 | PHASE1; PHASE2 |
| NCT02278510 | COMPLETED | Malignant Glioma; WHO Grade III or IV Recurrent Glioma |
Michael Vogelbaum, MD, PhD |
2014-12-09 | EARLY_PHASE1 |
| NCT01466855 | TERMINATED | Retinoblastoma |
Children's Hospital Medical Center, Cincinnati |
2011-10 | EARLY_PHASE1 |
| NCT01798004 | COMPLETED | Ganglioneuroblastoma; Stage 1 Neuroblastoma; Stage 2 Neuroblastoma; Stage 2A Neuroblastoma; Stage 2B Neuroblastoma; Stage 3 Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma |
Children's Oncology Group |
2013-04-09 | PHASE1 |
| NCT00800345 | COMPLETED | Gynecologic Tumors |
Vector Oncology |
2009-04 | PHASE1 |
| NCT00308165 | COMPLETED | Brain Neoplasms, Primary Malignant |
Columbia University |
2004-03 | PHASE1 |
| NCT00567567 | COMPLETED | Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S Neuroblastoma |
Children's Oncology Group |
2007-11-05 | PHASE3 |
| NCT01047891 | COMPLETED | Ovarian Cancer |
JSehouli |
2010-01 | PHASE2 |
| NCT01684878 | COMPLETED | Ovarian Cancer |
Hoffmann-La Roche |
2012-10-22 | PHASE3 |
| NCT01690598 | COMPLETED | Ovarian Cancer |
Vejle Hospital |
2012-11 | PHASE1; PHASE2 |
| NCT01736800 | WITHDRAWN | Central Nervous System (CNS) Metastases; Brain Metastases |
The Methodist Hospital Research Institute |
2007-03 | PHASE2 |
| NCT01533181 | COMPLETED | Recurrent Small Cell Lung Carcinoma |
National Cancer Institute (NCI) |
2012-02 | PHASE2 |
| NCT00550784 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
City of Hope Medical Center |
2001-01 | PHASE1 |
| NCT00634244 | COMPLETED | Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Minimally Differentiated Myeloid Leukemia (M0); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid Leukemia |
National Cancer Institute (NCI) |
2008-10 | PHASE2 |
| NCT00976911 | COMPLETED | Ovarian Cancer |
Hoffmann-La Roche |
2009-10-29 | PHASE3 |
| NCT00499616 | COMPLETED | Neuroblastoma |
Children's Oncology Group |
2007-10-08 | PHASE3 |
| NCT01904253 | TERMINATED | Small Cell Lung Cancer (SCLC) |
Taiho Oncology, Inc. |
2013-07 | PHASE2 |
| NCT01121406 | COMPLETED | Ovarian Neoplasms |
Boehringer Ingelheim |
2010-04 | PHASE2 |
| NCT01630018 | COMPLETED | Epithelial Ovarian Cancer |
Chong Kun Dang Pharmaceutical |
2011-01 | PHASE2 |
| NCT01840943 | TERMINATED | Epithelial Ovarian Cancer |
Xian-Janssen Pharmaceutical Ltd. |
2013-06 | PHASE3 |
| NCT01500720 | COMPLETED | Small Cell Lung Cancer |
Sanofi |
2012-03 | PHASE2 |
| NCT00812266 | TERMINATED | Extensive Disease; First-Line; Small Cell Lung Cancer |
Danish Oncological Lung Cancer Group |
2006-01 | PHASE3 |
| NCT00462787 | COMPLETED | Leukemia |
Memorial Sloan Kettering Cancer Center |
2007-04 | PHASE1 |
| NCT00186888 | COMPLETED | Retinoblastoma; Retinal Neoplasm |
St. Jude Children's Research Hospital |
2005-04-07 | PHASE3 |
| NCT00918320 | COMPLETED | Neuroblastoma; Brain Tumors; Solid Tumors |
Gustave Roussy, Cancer Campus, Grand Paris |
2009-06 | PHASE2 |
| NCT00325416 | COMPLETED | Multiple Myeloma |
H. Lee Moffitt Cancer Center and Research Institute |
2001-11-19 | PHASE1; PHASE2 |
| NCT00437307 | COMPLETED | Ovarian Cancer |
North Eastern German Society of Gynaecological Oncology |
2007-03 | PHASE3 |
| NCT00732420 | COMPLETED | Solid Tumours |
GlaxoSmithKline |
2008-09-24 | PHASE1 |
| NCT00477282 | COMPLETED | Ovarian Cancer |
BioNumerik Pharmaceuticals, Inc. |
2007-08 | PHASE3 |
| NCT00045175 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
University Health Network, Toronto |
2002-06 | PHASE1 |
| NCT00803062 | COMPLETED | Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Carcinoma; Stage IVB Cervical Cancer |
National Cancer Institute (NCI) |
2009-04 | PHASE3 |
| NCT00638898 | COMPLETED | Solid Tumor; Adult Central Nervous System Germ Cell Tumor; Adult Rhabdomyosarcoma; Childhood Central Nervous System Germ Cell Tumor; Childhood Soft Tissue Sarcoma; Ewing Sarcoma; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Ovarian Mixed Germ Cell Tumor; Previously Untreated Childhood Rhabdomyosarcoma; Recurrent Adult Brain Tumor; Recurrent Adult Soft Tissue Sarcoma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway and Hypothalamic Glioma; Recurrent Childhood Visual Pathway Glioma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Extragonadal Germ Cell Tumor; Recurrent Extragonadal Non-seminomatous Germ Cell Tumor; Recurrent Malignant Testicular Germ Cell Tumor; Recurrent Neuroblastoma; Recurrent Ovarian Germ Cell Tumor; Recurrent Wilms Tumor and Other Childhood Kidney Tumors; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific |
City of Hope Medical Center |
2007-02-26 | PHASE1 |
| NCT00170677 | COMPLETED | Ovarian Cancer |
North Eastern German Society of Gynaecological Oncology |
2005-09 | PHASE2 |
| NCT01017809 | WITHDRAWN | Ovarian Cancer |
NYU Langone Health |
2010-12 | |
| NCT00548418 | COMPLETED | Cervical Cancer |
Washington University School of Medicine |
2007-02 | PHASE2 |
| NCT00770731 | COMPLETED | Advanced Cancer |
M.D. Anderson Cancer Center |
2008-09 | PHASE1 |
| NCT01003938 | TERMINATED | Ovarian Cancer |
NYU Langone Health |
2009-08 | PHASE2 |
| NCT00828139 | COMPLETED | Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer |
National Cancer Institute (NCI) |
2009-05 | PHASE2 |
| NCT01004874 | COMPLETED | Malignant Glioma; Glioblastoma; Gliosarcoma |
Duke University |
2009-12-30 | PHASE2 |
| NCT00390806 | COMPLETED | Lung Cancer, Non-Small Cell |
GlaxoSmithKline |
2006-12 | PHASE3 |
| NCT01405235 | UNKNOWN | Recurrent, Persistent or Metastasized Cervical Cancer |
Institut fuer Frauengesundheit |
2006-09 | PHASE3 |
| NCT00980551 | WITHDRAWN | Retinoblastoma |
Children's Hospital Medical Center, Cincinnati |
2010-05 | |
| NCT01177501 | TERMINATED | Ovarian Cancer; Relapses |
Assistance Publique - Hôpitaux de Paris |
2009-04 | PHASE1 |
| NCT00483860 | COMPLETED | Solid Tumours |
GlaxoSmithKline |
2007-06-20 | PHASE1 |
| NCT00054444 | COMPLETED | Cervical Adenocarcinoma; Cervical Squamous Cell Carcinoma; Stage IB Cervical Cancer; Stage IIA Cervical Cancer; Stage IIB Cervical Cancer; Stage III Cervical Cancer; Stage IVA Cervical Cancer |
Gynecologic Oncology Group |
2007-09 | PHASE1 |
| NCT00770536 | COMPLETED | Cancer; Carcinoma; Fallopian Tube Cancer; Gynecological Malignancies; Metastases; Oncology; Ovarian Cancer; Solid Tumors; Tumors |
Amgen |
2009-01 | PHASE1 |
| NCT00057837 | COMPLETED | Extensive Stage Small Cell Lung Cancer |
Eastern Cooperative Oncology Group |
2004-07-14 | PHASE2 |
| NCT00365547 | COMPLETED | Lung Cancer |
Masonic Cancer Center, University of Minnesota |
2006-09 | PHASE2 |
| NCT00429559 | COMPLETED | Ovarian Cancer |
Hellenic Oncology Research Group |
2006-06 | PHASE1; PHASE2 |
| NCT01076400 | TERMINATED | Cervical Cancer |
Merck Sharp & Dohme LLC |
2010-05-31 | PHASE1; PHASE2 |
| NCT00541359 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
City of Hope Medical Center |
2004-01 | PHASE1 |
| NCT00547651 | COMPLETED | Small Cell Lung Cancer |
Celgene |
2007-09-01 | PHASE3 |
| NCT00807079 | COMPLETED | Cervical Cancer |
ARCAGY/ GINECO GROUP |
2008-09 | PHASE1; PHASE2 |
| NCT00313612 | TERMINATED | Recurrent Ovarian Epithelial Cancer |
National Cancer Institute (NCI) |
2006-01 | PHASE2 |
| NCT00379457 | UNKNOWN | Sarcoma |
European Paediatric Soft Tissue Sarcoma Study Group |
2006-06 | PHASE3 |
| NCT00842452 | COMPLETED | Cervical Cancer; Endometrial Cancer; Fallopian Tube Cancer; Ovarian Cancer; Sarcoma; Vaginal Cancer; Vulvar Cancer |
Steven Waggoner, MD |
2009-02 | PHASE1 |
| NCT00382733 | COMPLETED | Tumors |
Accelerated Community Oncology Research Network |
2006-11 | PHASE1; PHASE2 |
| NCT00682279 | WITHDRAWN | Advanced Solid Tumors |
GlaxoSmithKline |
2008-09 | PHASE1 |
| NCT00064077 | COMPLETED | Cervical Adenocarcinoma; Cervical Adenosquamous Carcinoma; Cervical Squamous Cell Carcinoma; Recurrent Cervical Carcinoma; Stage IVB Cervical Cancer |
Gynecologic Oncology Group |
2003-05 | PHASE3 |
| NCT00114166 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
2005-01 | PHASE2 |
| NCT00744081 | COMPLETED | AML |
Goethe University |
2004-07 | PHASE2 |
| NCT00410631 | UNKNOWN | Neuroblastoma |
German Society for Pediatric Oncology and Hematology GPOH gGmbH |
2004-10 | PHASE3 |
| NCT00117013 | COMPLETED | Neoplasms |
National Cancer Institute (NCI) |
2005-06-28 | PHASE1 |
| NCT00112619 | TERMINATED | Brain and Central Nervous System Tumors; Carcinoma of Unknown Primary; Leukemia; Lymphoma; Unspecified Childhood Solid Tumor, Protocol Specific |
Pediatric Brain Tumor Consortium |
2005-08 | PHASE1 |
| NCT00521144 | COMPLETED | Recurrent Small Cell Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2007-08 | PHASE1; PHASE2 |
| NCT00674674 | COMPLETED | Neoplastic Meningitis |
Baylor College of Medicine |
2005-10 | PHASE1 |
| NCT00765973 | COMPLETED | Small Cell Lung Cancer; Ovarian Cancer; Solid Tumors |
Spectrum Pharmaceuticals, Inc |
2008-11-10 | PHASE1 |
| NCT00098956 | COMPLETED | Extensive Stage Small Cell Lung Cancer; Recurrent Small Cell Lung Cancer |
National Cancer Institute (NCI) |
2005-01 | PHASE2 |
| NCT00703807 | COMPLETED | Endometrial Cancer |
Yale University |
2008-12 | PHASE1 |
| NCT00698516 | COMPLETED | Recurrent Small-cell Lung Cancer (SCLC); Lung Cancer, Small Cell |
GlaxoSmithKline |
2008-07 | PHASE2 |
| NCT00618813 | COMPLETED | Ewing Sarcoma of Bone; Localized Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor |
Children's Oncology Group |
2008-03 | |
| NCT00011986 | COMPLETED | Primary Peritoneal Carcinoma; Stage III Ovarian Cancer; Stage IV Ovarian Cancer |
Gynecologic Oncology Group |
2001-01 | PHASE3 |
| NCT00287963 | COMPLETED | Lung Cancer |
Medical University of South Carolina |
2004-02 | PHASE1 |
| NCT00502892 | COMPLETED | Solid Tumors |
M.D. Anderson Cancer Center |
2004-08 | PHASE1 |
| NCT00392340 | UNKNOWN | Neuroblastoma |
Children's Cancer and Leukaemia Group |
2008-03 | PHASE2 |
| NCT00087126 | COMPLETED | Cervical Cancer |
Gynecologic Oncology Group |
2005-02 | PHASE2 |
| NCT00826891 | UNKNOWN | Cervical Cancer |
Chinese Anti-Cancer Association |
2009-02 | PHASE2 |
| NCT00526799 | TERMINATED | Ovarian Cancer |
Daniela Matei, MD |
2007-09 | PHASE1; PHASE2 |
| NCT00343044 | COMPLETED | Ovarian Cancer; Fallopian Tube Cancer; Peritoneal Cancer |
Benaroya Research Institute |
2006-06 | PHASE2 |
| NCT00287911 | COMPLETED | Cervical Cancer |
Masonic Cancer Center, University of Minnesota |
2005-02 | PHASE1 |
| NCT00466232 | COMPLETED | Small Cell Carcinoma; Lung Cancer |
HealthPartners Institute |
2007-04 | PHASE1 |
| NCT00881166 | COMPLETED | Malignant Disease |
Astex Pharmaceuticals, Inc. |
2007-11 | PHASE1 |
| NCT00322751 | COMPLETED | Lung Cancer |
University of New Mexico |
2006-04 | PHASE1 |
| NCT00253461 | TERMINATED | Lung Cancer; Metastatic Cancer; Ovarian Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
Case Comprehensive Cancer Center |
2004-12 | EARLY_PHASE1 |
| NCT00720096 | TERMINATED | Ovarian Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
2008-07 | |
| NCT00697476 | TERMINATED | Small Cell Lung Cancer |
Armando Santoro, MD |
2009-01 | PHASE1; PHASE2 |
| NCT00610571 | COMPLETED | Glioblastoma; Gliosarcoma; Anaplastic Astrocytoma |
Katy Peters |
2004-04 | PHASE1 |
| NCT00523432 | COMPLETED | Genital Neoplasms, Female |
University of Chicago |
2007-08 | PHASE1 |
| NCT00516295 | COMPLETED | Ewing Sarcoma of Bone; Extraosseous Ewing Sarcoma; Peripheral Primitive Neuroectodermal Tumor; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor |
National Cancer Institute (NCI) |
2008-02 | PHASE2 |
| NCT00611468 | COMPLETED | Metastatic Solid Tumor |
Accelerated Community Oncology Research Network |
2006-06 | PHASE1 |
| NCT00808899 | TERMINATED | Neuroblastoma |
St. Jude Children's Research Hospital |
2008-12 | PHASE2 |
| NCT00305942 | COMPLETED | Carcinoma, Small Cell |
SCRI Development Innovations, LLC |
2006-03 | PHASE2 |
| NCT00316186 | COMPLETED | Lung Cancer, Small Cell |
GlaxoSmithKline |
2005-06 | PHASE2 |
| NCT00436644 | COMPLETED | Ovarian Cancer; Peritoneal Cavity Cancer |
Mayo Clinic |
2007-03 | PHASE2 |
| NCT00516438 | COMPLETED | Malignant Solid Tumors |
AstraZeneca |
2007-07 | PHASE1 |
| NCT00437073 | TERMINATED | Neoplasms, Breast |
GlaxoSmithKline |
2007-05 | PHASE2 |
| NCT00316173 | COMPLETED | Ovarian Cancer; Neoplasms, Ovarian |
GlaxoSmithKline |
2005-03 | PHASE2 |
| NCT00422682 | COMPLETED | Tumors |
Sanofi |
2007-01 | PHASE1 |
| NCT00397293 | COMPLETED | Small Cell Lung Cancer |
Ascenta Therapeutics |
2006-11 | PHASE1; PHASE2 |
| NCT00389766 | WITHDRAWN | Neuroblastoma |
Children's Cancer and Leukaemia Group |
2008-07 | PHASE2 |
| NCT00319969 | COMPLETED | Small Cell Lung Cancer |
Celgene Corporation |
2006-04 | PHASE2 |
| NCT00315861 | COMPLETED | Ovarian Cancer; Endometrial Cancer; Cervical Cancer; Lung Cancer |
SCRI Development Innovations, LLC |
2006-03 | PHASE1 |
| NCT00327171 | COMPLETED | Neoplasms; Cancer of the Ovary |
Sanofi |
2006-05 | PHASE2 |
| NCT00028743 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
NCIC Clinical Trials Group |
2001-08-31 | PHASE3 |
| NCT00553189 | COMPLETED | Solid Tumors; Lymphomas |
National Cancer Institute (NCI) |
2007-08-09 | PHASE1 |
| NCT00215956 | COMPLETED | Rectal Neoplasms |
H. Lee Moffitt Cancer Center and Research Institute |
2001-11 | PHASE1 |
| NCT00257816 | COMPLETED | Cervical Cancer |
University of California, Irvine |
2004-01 | PHASE2 |
| NCT00460876 | COMPLETED | Retinoblastoma |
Hospital JP Garrahan |
2007-03 | PHASE1 |
| NCT00267488 | COMPLETED | Neoplasms, Endometrial; Endometrial Cancer |
GlaxoSmithKline |
2005-10 | PHASE2 |
| NCT00130858 | COMPLETED | Sarcoma, Soft Tissue |
Cooperative Weichteilsarkom Study Group |
2005-01 | PHASE2 |
| NCT00388089 | COMPLETED | Lung Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
University of California, Davis |
2004-12 | PHASE1 |
| NCT00003958 | COMPLETED | Adult Malignant Mesenchymoma; Adult Rhabdomyosarcoma; Alveolar Childhood Rhabdomyosarcoma; Childhood Malignant Mesenchymoma; Embryonal Childhood Rhabdomyosarcoma; Embryonal-botryoid Childhood Rhabdomyosarcoma; Nonmetastatic Childhood Soft Tissue Sarcoma; Previously Untreated Childhood Rhabdomyosarcoma; Stage I Adult Soft Tissue Sarcoma; Stage II Adult Soft Tissue Sarcoma; Stage III Adult Soft Tissue Sarcoma |
Children's Oncology Group |
2002-09 | PHASE3 |
| NCT00541138 | COMPLETED | Brain and Central Nervous System Tumors; Metastatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
City of Hope Medical Center |
2003-05 | PHASE2 |
| NCT00004188 | COMPLETED | Neuroblastoma |
Children's Oncology Group |
2001-02 | PHASE3 |
| NCT00107471 | TERMINATED | Brain Tumors; Central Nervous System Tumors |
Children's Oncology Group |
2005-10 | PHASE1; PHASE2 |
| NCT00294190 | COMPLETED | Small Cell Lung Cancer; Carcinoma, Small Cell |
SCRI Development Innovations, LLC |
2006-02 | PHASE2 |
| NCT00065182 | COMPLETED | Lung Cancer, Non-Small Cell; Non-Small-Cell Lung Cancer |
GlaxoSmithKline |
2003-08-14 | PHASE2 |
| NCT00361803 | COMPLETED | Cancer |
GlaxoSmithKline |
2006-09-12 | PHASE1 |
| NCT00259935 | COMPLETED | Lung Cancer, Small Cell |
GlaxoSmithKline |
2004-10-04 | PHASE1 |
| NCT00002913 | COMPLETED | Brenner Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mixed Epithelial Carcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Ovarian Undifferentiated Adenocarcinoma; Stage III Ovarian Epithelial Cancer; Stage IV Ovarian Epithelial Cancer |
National Cancer Institute (NCI) |
1996-12 | PHASE1 |
| NCT00518193 | TERMINATED | Cervix Cancer |
ARCAGY/ GINECO GROUP |
2007-04 | PHASE2 |
| NCT00315211 | TERMINATED | Mediastinal Neoplasms |
Aultman Health Foundation |
2004-11 | PHASE2 |
| NCT00135135 | COMPLETED | Neuroblastoma |
St. Jude Children's Research Hospital |
2005-08 | PHASE2 |
| NCT00003211 | COMPLETED | Brain and Central Nervous System Tumors |
St. Jude Children's Research Hospital |
1996-10 | PHASE2 |
| NCT00320359 | COMPLETED | Lung Cancer, Small Cell |
GlaxoSmithKline |
2002-08 | PHASE3 |
| NCT00628732 | COMPLETED | Solid Tumors |
Children's Medical Center Dallas |
2005-01 | PHASE2 |
| NCT00005026 | COMPLETED | Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
2000-02 | PHASE1 |
| NCT00033696 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
2001-09 | PHASE2 |
| NCT00040872 | COMPLETED | Neuroblastoma |
Memorial Sloan Kettering Cancer Center |
2000-06 | PHASE2 |
| NCT00003945 | COMPLETED | Cervical Cancer |
Gynecologic Oncology Group |
1999-06 | PHASE3 |
| NCT00053287 | COMPLETED | Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases |
Case Comprehensive Cancer Center |
2002-09 | PHASE2 |
| NCT00276796 | COMPLETED | Cervical Cancer |
Gynecologic Oncology Group |
PHASE2 | |
| NCT00057720 | COMPLETED | Ovarian Neoplasms |
Telik |
2003-06 | PHASE3 |
| NCT00003255 | COMPLETED | Leukemia |
Alliance for Clinical Trials in Oncology |
1999-11 | PHASE2 |
| NCT00287859 | TERMINATED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
Masonic Cancer Center, University of Minnesota |
2004-08 | PHASE1 |
| NCT00006373 | COMPLETED | Lymphoma |
H. Lee Moffitt Cancer Center and Research Institute |
2000-02 | PHASE2 |
| NCT00070200 | COMPLETED | Neuroblastoma |
Children's Oncology Group |
2004-03 | PHASE1 |
| NCT00005990 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
NYU Langone Health |
2000-08 | PHASE1 |
| NCT00158886 | TERMINATED | Carcinoma, Renal Cell |
GlaxoSmithKline |
2001-11-08 | PHASE1 |
| NCT00006454 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer |
AGO Study Group |
1999-12 | PHASE3 |
| NCT00006125 | COMPLETED | Lymphoma |
Alliance for Clinical Trials in Oncology |
2000-07 | PHASE2 |
| NCT00005792 | COMPLETED | Multiple Myeloma; Plasma Cell Neoplasm |
H. Lee Moffitt Cancer Center and Research Institute |
1998-06-02 | PHASE1 |
| NCT00005793 | COMPLETED | Leukemia |
H. Lee Moffitt Cancer Center and Research Institute |
1999-07 | PHASE1; PHASE2 |
| NCT00109798 | WITHDRAWN | Central Nervous System Tumors; Lymphoma |
The Methodist Hospital Research Institute |
2005-03 | |
| NCT01039025 | COMPLETED | Myeloma |
M.D. Anderson Cancer Center |
2002-02-18 | PHASE2 |
| NCT00006012 | COMPLETED | Drug/Agent Toxicity by Tissue/Organ; Lung Cancer; Radiation Toxicity |
Alliance for Clinical Trials in Oncology |
2001-02 | PHASE1; PHASE2 |
| NCT00097019 | COMPLETED | Ovarian Cancer |
Genentech, Inc. |
2005-02 | PHASE2 |
| NCT00003382 | TERMINATED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
1998-05 | PHASE1 |
| NCT00002693 | COMPLETED | Leukemia; Neutropenia |
Mayo Clinic |
1995-10 | PHASE1 |
| NCT00193167 | COMPLETED | Colon Cancer |
SCRI Development Innovations, LLC |
2004-01 | PHASE2 |
| NCT00005811 | COMPLETED | AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Primary CNS Lymphoma; AIDS-related Small Noncleaved Cell Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; HIV-associated Hodgkin Lymphoma; Leptomeningeal Metastases; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Unspecified Childhood Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2000-04 | PHASE2 |
| NCT00003967 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
1999-09 | PHASE1 |
| NCT00252889 | COMPLETED | Small Cell Lung Cancer; Pancreatic Cancer; Head and Neck Cancer; Gastric Cancer; Esophageal Cancer |
Christiana Care Health Services |
2004-05 | PHASE1 |
| NCT00003281 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
1998-04 | PHASE2 |
| NCT00002537 | COMPLETED | Lung Cancer |
National Cancer Institute (NCI) |
1993-09 | PHASE1 |
| NCT00068484 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
2003-07 | PHASE1 |
| NCT00217555 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
Fred Hutchinson Cancer Center |
2002-07 | PHASE2 |
| NCT00087048 | TERMINATED | Lung Cancer |
Case Comprehensive Cancer Center |
2004-04 | PHASE2 |
| NCT00334867 | WITHDRAWN | Sarcoma |
Children's Oncology Group |
2005-12 | PHASE3 |
| NCT00043862 | COMPLETED | Lung Cancer, Small Cell; Small Cell Lung Cancer |
GlaxoSmithKline |
2002-08 | PHASE2 |
| NCT00028925 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
2001-11 | PHASE2 |
| NCT00005962 | COMPLETED | Leukemia |
Eastern Cooperative Oncology Group |
2000-10-04 | PHASE2 |
| NCT00193245 | COMPLETED | Lung Cancer |
SCRI Development Innovations, LLC |
2000-11 | PHASE2 |
| NCT00003156 | TERMINATED | Sarcoma |
Gynecologic Oncology Group |
1998-06 | PHASE2 |
| NCT00004006 | COMPLETED | Retinoblastoma |
St. Jude Children's Research Hospital |
1997-11 | PHASE2 |
| NCT00170625 | COMPLETED | Ovarian Cancer |
North Eastern German Society of Gynaecological Oncology |
2004-06 | PHASE1; PHASE2 |
| NCT00193297 | COMPLETED | Ovary Cancer |
SCRI Development Innovations, LLC |
2002-02 | PHASE2 |
| NCT00250094 | COMPLETED | Ovarian Cancer |
New Mexico Cancer Research Alliance |
2004-05 | PHASE1 |
| NCT00113789 | COMPLETED | Ovarian Cancer |
Amgen |
2003-10 | PHASE2 |
| NCT00002515 | COMPLETED | Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Head and Neck Cancer; Kidney Cancer; Liver Cancer; Lymphoma; Neuroblastoma; Ovarian Cancer; Retinoblastoma; Sarcoma; Testicular Germ Cell Tumor |
Memorial Sloan Kettering Cancer Center |
1992-10 | PHASE2 |
| NCT00072267 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
University Health Network, Toronto |
2004-01 | PHASE2 |
| NCT00025272 | COMPLETED | Lung Cancer |
Wake Forest University Health Sciences |
2001-11-01 | PHASE2 |
| NCT00193388 | COMPLETED | Lung Cancer |
SCRI Development Innovations, LLC |
2002-09 | PHASE2 |
| NCT00004186 | COMPLETED | Lung Cancer |
University of Alabama at Birmingham |
1996-12 | PHASE1; PHASE2 |
| NCT00006391 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
NYU Langone Health |
2000-08 | PHASE1 |
| NCT00084565 | WITHDRAWN | Prostate Cancer |
Fox Chase Cancer Center |
2003-11 | PHASE2 |
| NCT00061308 | COMPLETED | Peritoneal Cancer; Ovarian Cancer; Neoplasms, Ovarian; Fallopian Tube Cancer |
GlaxoSmithKline |
2002-12 | PHASE2 |
| NCT00193570 | COMPLETED | Cancer |
SCRI Development Innovations, LLC |
2002-02 | PHASE1 |
| NCT00004055 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
1999-11 | PHASE2 |
| NCT00193401 | COMPLETED | Lung Cancer |
SCRI Development Innovations, LLC |
2002-08 | PHASE2 |
| NCT00003812 | COMPLETED | Lung Cancer |
Alliance for Clinical Trials in Oncology |
1999-03 | PHASE2 |
| NCT00320983 | COMPLETED | Cervical Cancer |
University of New Mexico |
2002-03 | PHASE1 |
| NCT00002986 | COMPLETED | Brain and Central Nervous System Tumors |
Duke University |
1997-02 | PHASE1 |
| NCT00193583 | COMPLETED | Cancer |
SCRI Development Innovations, LLC |
2003-05 | PHASE1 |
| NCT00038545 | COMPLETED | Non-Hodgkin's Lymphoma |
M.D. Anderson Cancer Center |
2001-05-18 | PHASE2 |
| NCT00046111 | COMPLETED | Lung Cancer, Small Cell; Solid Tumor Cancer |
GlaxoSmithKline |
2001-09 | PHASE1 |
| NCT00049998 | COMPLETED | Non-Small-Cell Lung Cancer |
GlaxoSmithKline |
2001-10 | PHASE3 |
| NCT00004137 | COMPLETED | Lung Cancer |
SWOG Cancer Research Network |
1999-10 | PHASE2 |
| NCT00005612 | TERMINATED | Ovarian Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
1999-08 | PHASE1; PHASE2 |
| NCT00005029 | TERMINATED | Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Gynecologic Oncology Group |
2000-02 | PHASE2 |
| NCT00002948 | TERMINATED | Unspecified Adult Solid Tumor, Protocol Specific |
Yale University |
1996-10 | PHASE1 |
| NCT00043927 | COMPLETED | Small Cell Lung Cancer |
GlaxoSmithKline |
2001-04 | PHASE3 |
| NCT00187083 | COMPLETED | Acute Lymphoblastic Leukemia |
St. Jude Children's Research Hospital |
1997-02 | PHASE3 |
| NCT00025311 | COMPLETED | Brain and Central Nervous System Tumors |
NYU Langone Health |
2001-05 | PHASE1 |
| NCT00014443 | TERMINATED | Brain and Central Nervous System Tumors |
Rush University Medical Center |
2000-08 | PHASE2 |
| NCT00003745 | COMPLETED | Sarcoma |
National Cancer Institute (NCI) |
1999-05 | PHASE2 |
| NCT00002643 | COMPLETED | Neutropenia; Sarcoma |
National Cancer Institute (NCI) |
1995-04 | PHASE2 |
| NCT00005021 | COMPLETED | Lymphoma; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific |
Fox Chase Cancer Center |
1996-07 | PHASE1 |
| NCT00005051 | COMPLETED | Ovarian Cancer |
NYU Langone Health |
1999-08 | PHASE2 |
| NCT00003194 | TERMINATED | Unspecified Childhood Solid Tumor, Protocol Specific |
Seattle Children's Hospital |
1997-07 | PHASE1 |
| NCT00041015 | COMPLETED | Lung Cancer |
Case Comprehensive Cancer Center |
2001-09 | PHASE3 |
| NCT00003735 | COMPLETED | Leukemia |
Children's Oncology Group |
1998-12 | PHASE2 |
| NCT00652691 | COMPLETED | Ovarian Cancer; Peritoneal Cavity Cancer |
Mayo Clinic |
1998-08 | PHASE1 |
| NCT00005593 | COMPLETED | Leukemia; Myelodysplastic Syndromes |
Case Comprehensive Cancer Center |
1998-09 | PHASE1 |
| NCT00002950 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Yale University |
1996-09-26 | PHASE1; PHASE2 |
| NCT00004221 | TERMINATED | Malignant Ovarian Mixed Epithelial Tumor; Ovarian Clear Cell Cystadenocarcinoma; Ovarian Endometrioid Adenocarcinoma; Ovarian Mucinous Cystadenocarcinoma; Ovarian Serous Cystadenocarcinoma; Primary Peritoneal Carcinoma; Stage III Ovarian Cancer; Undifferentiated Ovarian Carcinoma |
Gynecologic Oncology Group |
1999-11 | PHASE2 |
| NCT00003675 | COMPLETED | Leukemia; Myelodysplastic Syndromes |
Alliance for Clinical Trials in Oncology |
1999-03 | PHASE2 |
| NCT00003331 | COMPLETED | Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Precancerous Condition; Unspecified Adult Solid Tumor, Protocol Specific |
NYU Langone Health |
1998-01 | PHASE1 |
| NCT00003917 | COMPLETED | Lung Cancer |
Case Comprehensive Cancer Center |
1999-03 | PHASE3 |
| NCT00006374 | WITHDRAWN | Lung Cancer |
Case Comprehensive Cancer Center |
1999-10 | PHASE2 |
| NCT00186849 | COMPLETED | Neuroblastoma |
St. Jude Children's Research Hospital |
1997-10 | PHASE2 |
| NCT00002734 | COMPLETED | Ovarian Cancer; Primary Peritoneal Cavity Cancer |
National Cancer Institute (NCI) |
1996-03 | PHASE1 |
| NCT00002814 | COMPLETED | Brain and Central Nervous System Tumors |
Dartmouth-Hitchcock Medical Center |
1996-08 | PHASE2 |
| NCT00006032 | TERMINATED | Breast Cancer |
H. Lee Moffitt Cancer Center and Research Institute |
2000-03 | PHASE2 |
| NCT00002705 | COMPLETED | Leukemia |
National Cancer Institute (NCI) |
1996-04 | PHASE1 |
| NCT00100477 | COMPLETED | Non-Hodgkin's Lymphoma; Leukemia |
US Department of Veterans Affairs |
1998-08 | PHASE2 |
| NCT00003297 | COMPLETED | Ovarian Cancer |
Georgetown University |
1997-12 | PHASE1; PHASE2 |
| NCT00002587 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
National Cancer Institute (NCI) |
1994-09 | PHASE1 |
| NCT00003943 | COMPLETED | Carcinoma of Unknown Primary; Lung Cancer |
Fox Chase Cancer Center |
1998-09 | PHASE2 |
| NCT00003372 | COMPLETED | Brain and Central Nervous System Tumors |
NCIC Clinical Trials Group |
1997-12-08 | PHASE2 |
| NCT00004060 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Daiichi Sankyo |
1999-07 | PHASE2 |
| NCT00002588 | COMPLETED | Leukemia |
Case Comprehensive Cancer Center |
1994-08 | PHASE1 |
| NCT00003198 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Memorial Sloan Kettering Cancer Center |
1997-11 | PHASE1 |
| NCT00002625 | COMPLETED | Esophageal Cancer; Lung Cancer; Lymphoma |
National Cancer Institute (NCI) |
1995-03 | PHASE1 |
| NCT00003340 | COMPLETED | Leukemia |
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins |
1997-11 | PHASE2 |
| NCT00003944 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cavity Cancer |
Fox Chase Cancer Center |
1998-08 | PHASE2 |
| NCT00187031 | COMPLETED | Wilms Tumor |
St. Jude Children's Research Hospital |
2002-11 | PHASE2 |
| NCT00194935 | TERMINATED | Ovarian Cancer |
Weill Medical College of Cornell University |
2003-02 | PHASE2 |
| NCT00312988 | COMPLETED | Ovarian Cancer |
North Eastern German Society of Gynaecological Oncology |
2000-01 | PHASE3 |
| NCT00276276 | COMPLETED | Lung Cancer, Small Cell |
GlaxoSmithKline |
2000-11 | PHASE3 |
| NCT00001333 | COMPLETED | Leukemia; Lymphoma; Meningeal Neoplasms |
National Cancer Institute (NCI) |
1993-02 | PHASE1 |
| NCT00003065 | COMPLETED | Cervical Cancer |
Herbert Irving Comprehensive Cancer Center |
1997-01 | PHASE2 |
| NCT00003619 | COMPLETED | Chronic Myeloproliferative Disorders; Leukemia; Myelodysplastic Syndromes; Thrombocytopenia |
Drexel University College of Medicine |
1998-02 | PHASE1; PHASE2 |
| NCT00004979 | COMPLETED | Unspecified Adult Solid Tumor, Protocol Specific |
Jonsson Comprehensive Cancer Center |
PHASE1; PHASE2 | |
| NCT00003827 | UNKNOWN | Leukemia; Myelodysplastic Syndromes |
ALZA |
1999-01 | PHASE2 |
| NCT00001335 | COMPLETED | Ewing's Sarcoma; Neuroblastoma; Rhabdomyosarcoma |
National Cancer Institute (NCI) |
1993-04 | PHASE2 |
| NCT00003732 | COMPLETED | Ovarian Cancer |
Rigshospitalet, Denmark |
1998-09 | PHASE2 |
| NCT00488709 | COMPLETED | Acute Myeloid Leukemia |
PETHEMA Foundation |
2003-05 | PHASE4 |
| NCT00189566 | COMPLETED | Ovarian Cancer; Fallopian Tube Cancer; Malignant Tumor of Peritoneum |
ARCAGY/ GINECO GROUP |
2004-04 | PHASE2 |
| NCT00002395 | COMPLETED | HIV Infections; Leukoencephalopathy, Progressive Multifocal |
SmithKline Beecham |
PHASE2 | |
| NCT00179712 | COMPLETED | Ovarian Cancer |
Celgene Corporation |
2005-04 | PHASE1; PHASE2 |
| NCT00295243 | COMPLETED | Advanced Solid Malignancies |
Mayo Clinic |
2004-09 | PHASE1 |
| NCT00231855 | COMPLETED | Ovarian Neoplasms; Uterine Neoplasms |
Montefiore Medical Center |
2004-11 | PHASE2 |
| NCT00003415 | COMPLETED | Leukemia; Myelodysplastic Syndromes |
University of Arizona |
1998-09 | PHASE1; PHASE2 |
| NCT00006199 | UNKNOWN | Cancer |
National Center for Research Resources (NCRR) |
PHASE1 | |
| NCT00502762 | UNKNOWN | Lung Cancer; Refractory to Chemotherapy |
Gachon University Gil Medical Center |
2004-09 | PHASE2 |
| NCT00003733 | UNKNOWN | Ovarian Cancer |
SmithKline Beecham |
1997-12 | PHASE2 |
| NCT00322920 | TERMINATED | Cervix Cancer |
University of Alabama at Birmingham |
2005-07 | PHASE1 |
| NCT00888810 | TERMINATED | Cancer; Ovarian; Relapse; Chemotherapy |
Centre Francois Baclesse |
2008-03 | PHASE2 |
| NCT00314678 | COMPLETED | Epithelial Ovarian Cancer; Primary Peritoneal Cancer |
John P. Fruehauf |
2005-09 | PHASE2 |
| NCT00055614 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Beth Israel Deaconess Medical Center |
2002-05 | PHASE1 |
| NCT00102375 | COMPLETED | Ovarian Cancer |
AGO Study Group |
1999-12 | PHASE3 |
| NCT00003064 | UNKNOWN | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
Herbert Irving Comprehensive Cancer Center |
1997-01 | PHASE1; PHASE2 |
| NCT00046800 | COMPLETED | Ovarian Neoplasms |
Astellas Pharma Inc |
2002-09 | PHASE2 |
| NCT00014690 | COMPLETED | Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer |
AstraZeneca |
2001-03 | PHASE2 |
| NCT00412503 | COMPLETED | Refractory Tumors; Malignant Tumors |
Gustave Roussy, Cancer Campus, Grand Paris |
PHASE1 |
(data from https://clinicaltrials.gov, updated on 2026-02-12)
Check the
Topotecan HCl
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Mechanism and Biochemical Profile
Appendix RUO and cGMP Quality Standards
| Quality Dimension | RUO (Research Use Only) | cGMP (Current Good Manufacturing Practice) |
|---|---|---|
| Clinical Applicability | Prohibited in human clinical trials or medical diagnostics. | Mandatory for human clinical trials (Phase I–III) and therapies. |
| Regulatory Status | Non-regulated grade; exempt from drug manufacturing laws. | Legally enforced by health authorities (e.g., FDA, EMA, NMPA). |
| Facility Environment | Unclassified analytical or research laboratories. | Validated Cleanrooms (ISO Class 5–8) with continuous monitoring. |
| Quality Control | Basic purity and activity testing. | Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma). |
| Process Validation | Basic equipment calibration; no process validation required. | Full qualification (IQ/OQ/PQ) and complete batch records. |
| Quality Assurance | Vendor self-declared without required formal QMS. | Mandatory QA/QC unit, Change Control, CAPA, and vendor audits. |
| Regulatory Impact | High risk of IND rejection if used as a critical raw material. | Required for IND/NDA filings, supported by Drug Master Files (DMF). |
Footnotes
Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).
Note: Technical data last updated: Sep 1, 2026.