CAS No. 139404-48-1

Batch: Purity:100.00
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Tiotropium Bromide hydrate Chemical Structure
Chemical Structure
Check the Tiotropium Bromide hydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 139404-48-1
Molecular Formula

C19H22NO4S2.Br.xH2O
Molecular Weight (MW) 490.43
SMILES C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C.O.[Br-]

Ordering Information

Biological Activity

Tiotropium Bromide hydrate is a long-acting muscarinic receptor antagonist that acts as an anticholinergic bronchodilator. It targets M3 muscarinic receptors located on airway smooth muscle cells and submucosal glands, blocking cholinergic signaling to prevent smooth muscle contraction and excessive mucus secretion. This inhibition attenuates airway constriction and provides sustained bronchodilation, making it effective for managing symptoms of chronic obstructive pulmonary disease. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 8 mg/mL (16.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.