CAS No. 518-34-3
Batch:
Purity:99.95
Chemical Structure
Check the
Tetrandrine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene | |
|---|---|---|
| CAS Number | 518-34-3 | |
| Molecular Formula |
C38H42N2O6 |
|
| Molecular Weight (MW) | 622.75 | |
| InChIKey | WVTKBKWTSCPRNU-KYJUHHDHSA-N |
Tetrandrine is a bis-benzylisoquinoline alkaloid and calcium channel blocker with anti-inflammatory and antineoplastic activities. It induces G1 phase cell cycle arrest and apoptosis through the upregulation of p21, downregulation of cyclin D1, and activation of caspase-3. Furthermore, tetrandrine alters cytoskeletal architecture by reorganizing F-actin distribution and inhibiting endosomal two-pore calcium channels. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
12 mg/mL
(19.26 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
5 mg/mL
(8.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
| DMSO |
2 mg/mL
(3.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
| DMSO |
7 mg/mL
(11.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
17 mg/mL
(27.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 6 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.