CAS No. 91161-71-6

Batch: Purity:99.96
Check CoA
Terbinafine Chemical Structure
Chemical Structure
Check the Terbinafine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
CAS Number 91161-71-6
Molecular Formula

C21H25N
Molecular Weight (MW) 291.43
SMILES CC(C)(C)C#CC=CCN(C)CC1=CC=CC2=CC=CC=C21
InChIKey DOMXUEMWDBAQBQ-WEVVVXLNSA-N

Ordering Information

Biological Activity

Terbinafine is an allylamine antifungal agent that acts as a potent inhibitor of fungal squalene epoxidase. By specifically blocking this critical enzyme in the ergosterol biosynthetic pathway, terbinafine induces intracellular accumulation of squalene while depleting ergosterol levels. This disruption severely compromises fungal cell membrane integrity and function, ultimately producing a fungicidal phenotype against dermatophytes and opportunistic fungi. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 58 mg/mL (199.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 58 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.