CAS No. 118292-40-3

Batch: Purity:99.98
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Tazarotene Chemical Structure
Chemical Structure
Check the Tazarotene product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate
CAS Number 118292-40-3
Molecular Formula

C21H21NO2S
Molecular Weight (MW) 351.46
SMILES CCOC(=O)C1=CN=C(C=C1)C#CC2=CC3=C(C=C2)SCCC3(C)C
InChIKey OGQICQVSFDPSEI-UHFFFAOYSA-N

Biological Activity

Tazarotene is a synthetic retinoid prodrug that is rapidly de-esterified to its active metabolite, tazarotenic acid, which functions as a selective retinoic acid receptor (RAR) agonist with affinity for RARβ and RARγ. Activation of the RAR signaling pathway regulates gene transcription involved in cell proliferation, epidermal differentiation, and inflammatory responses, resulting in inhibited keratinocyte proliferation and attenuated cutaneous inflammation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 10 mg/mL (28.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nagpal S, et al. J Biol Chem. 1995;270(2):923-7.

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Note: Technical data last updated: Sep 1, 2026.