CAS No. 252916-29-3
| IUPAC Name | 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid | |
|---|---|---|
| CAS Number | 252916-29-3 | |
| Molecular Formula |
C18H18N2O3 |
|
| Molecular Weight (MW) | 310.35 | |
| SMILES | CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O | |
| InChIKey | NHFDRBXTEDBWCZ-ZROIWOOFSA-N |
Orantinib (SU6668) is a multi-targeted receptor tyrosine kinase inhibitor that selectively targets PDGFR, VEGFR, and FGFR. It inhibits ligand-induced receptor autophosphorylation, thereby downregulating downstream vascular endothelial signaling pathways. This inhibition induces apoptosis in endothelial cells and disrupts existing tumor microvessels, leading to the suppression of tumor angiogenesis, primary tumor growth, and metastatic dissemination across various preclinical xenograft models. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
62 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
62 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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