CAS No. 677297-51-7
Batch:
Purity:99.44
Chemical Structure
Check the
TG100-115
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol | |
|---|---|---|
| CAS Number | 677297-51-7 | |
| Molecular Formula |
C18H14N6O2 |
|
| Molecular Weight (MW) | 346.34 | |
| SMILES | C1=CC(=CC(=C1)O)C2=NC3=C(N=C(N=C3N=C2C4=CC(=CC=C4)O)N)N | |
| InChIKey | UJIAQDJKSXQLIT-UHFFFAOYSA-N |
Biological Activity
TG100-115 is an isoform-selective PI3K inhibitor targeting PI3Kγ (IC50 = 83 nM) and PI3Kδ (IC50 = 235 nM), while showing minimal activity against PI3Kα and PI3Kβ. By blocking PI3Kγ/δ signaling, this compound suppresses downstream inflammatory pathways, leading to reduced inflammatory cell infiltration, attenuated tissue inflammation, and decreased mucin accumulation in preclinical models of respiratory diseases such as asthma. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
9 mg/mL
(25.98 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.