CAS No. 2447-57-6
| CAS Number | 2447-57-6 | |
|---|---|---|
| Molecular Formula |
C12H14N4O4S |
|
| Molecular Weight (MW) | 310.33378 | |
| SMILES | COC1=C(N=CN=C1OC)NS(=O)(=O)C2=CC=C(C=C2)N |
Sulfadoxine is a long-acting sulfonamide derivative that acts as an inhibitor of dihydropteroate synthase (DHPS) within the folate biosynthesis pathway. By inhibiting DHPS, sulfadoxine depletes essential folate precursors, thereby suppressing parasite nucleic acid synthesis and cell proliferation in Plasmodium species. When combined with the dihydrofolate reductase inhibitor pyrimethamine, sulfadoxine displays potent synergistic antimalarial activity through dual inhibition of the folate metabolic pathway. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
62 mg/mL
(199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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