CAS No. 3056-17-5
Batch:
Purity:99.74
Chemical Structure
Check the
d4T (Stavudine)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione | |
|---|---|---|
| CAS Number | 3056-17-5 | |
| Molecular Formula |
C10H12N2O4 |
|
| Molecular Weight (MW) | 224.21 | |
| SMILES | CC1=CN(C(=O)NC1=O)C2C=CC(O2)CO | |
| InChIKey | XNKLLVCARDGLGL-JGVFFNPUSA-N |
Stavudine (d4T) is a thymidine nucleoside analog reverse transcriptase inhibitor (NARTI) that targets viral reverse transcriptase. Intracellular kinases phosphorylate stavudine to its active form, stavudine triphosphate, which competes with natural thymidine triphosphate for binding to HIV reverse transcriptase. Incorporation of stavudine triphosphate into nascent viral cDNA causes DNA chain termination, thereby effectively disrupting viral genome synthesis and blocking HIV replication. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
49 mg/mL
(218.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 24 mg/mL |
| Water | Insoluble |
| DMSO |
45 mg/mL
(200.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
| DMSO |
45 mg/mL
(200.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
| DMSO |
45 mg/mL
(200.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 45 mg/mL |
| Ethanol | 20 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.