CAS No. 114-49-8

Batch: Purity:99.99
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Scopolamine (LSM-4015) HBr Chemical Structure
Chemical Structure
Check the Scopolamine (LSM-4015) HBr product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl] (2S)-3-hydroxy-2-phenylpropanoate;hydrobromide
CAS Number 114-49-8
Molecular Formula

C17H21NO4.HBr
Molecular Weight (MW) 384.26
SMILES CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4.Br
InChIKey WTGQALLALWYDJH-WYHSTMEOSA-N

Biological Activity

Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist that selectively blocks muscarinic acetylcholine receptors, with high affinity for the M1 receptor subtype. By inhibiting muscarinic acetylcholine receptor activation, scopolamine disrupts downstream cholinergic signaling pathways in central and peripheral neural networks. This antagonism suppresses cholinergic-mediated signaling cascades, altering cellular excitability and neuro-pathway activity involved in cholinergic transmission. [1][2]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 77 mg/mL (200.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 77 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Caulfield MP, et al. Pharmacol Rev. 1998;50(2):279-90.

[2] Felder CC. FASEB J. 1995;9(8):619-25.

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Note: Technical data last updated: Sep 1, 2026.