CAS No. 929016-96-6

Batch: Purity:99.99
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Pracinostat (SB939) Chemical Structure
Chemical Structure
Check the Pracinostat (SB939) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-3-[2-butyl-1-[2-(diethylamino)ethyl]benzimidazol-5-yl]-N-hydroxyprop-2-enamide
CAS Number 929016-96-6
Molecular Formula

C20H30N4O2
Molecular Weight (MW) 358.48
SMILES CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO
InChIKey JHDKZFFAIZKUCU-ZRDIBKRKSA-N

Ordering Information

Biological Activity

Pracinostat (SB939) is an orally active pan-histone deacetylase (HDAC) inhibitor targeting class I, II, and IV HDACs, including HDAC1. By blocking HDAC enzymatic activity, Pracinostat increases histone acetylation and modulates downstream gene expression, ultimately leading to cell cycle arrest and apoptosis in tumor cells. Furthermore, it demonstrates potent antiproliferative activity across various cancer cell lines, including colorectal carcinoma and acute myeloid leukemia. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 72 mg/mL (200.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 27 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.