CAS No. 940929-33-9

Batch: Purity:99.34
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SB743921 HCl Chemical Structure
Chemical Structure
Check the SB743921 HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(3-aminopropyl)-N-[(1R)-1-(3-benzyl-7-chloro-4-oxochromen-2-yl)-2-methylpropyl]-4-methylbenzamide
CAS Number 940929-33-9
Molecular Formula

C31H33N2O3.HCl
Molecular Weight (MW) 553.52
SMILES CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=C(C(=O)C3=C(O2)C=C(C=C3)Cl)CC4=CC=CC=C4)C(C)C.Cl
InChIKey PGXYIBJJCLWJST-MUUNZHRXSA-N

Ordering Information

Biological Activity

SB743921 is a potent kinesin spindle protein (KSP, also known as Eg5) inhibitor. Inhibition of KSP disrupts mitotic spindle assembly during cell division, leading to the formation of monoastral mitotic spindles. This blockade prevents proper chromosome segregation and activates the spindle assembly checkpoint, resulting in mitotic arrest and subsequent apoptotic cell death in proliferating tumor cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (180.66 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water 46 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.