CAS No. 501919-59-1
| IUPAC Name | 2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid | |
|---|---|---|
| CAS Number | 501919-59-1 | |
| Molecular Formula |
C16H15NO7S |
|
| Molecular Weight (MW) | 365.36 | |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O | |
| InChIKey | HWNUSGNZBAISFM-UHFFFAOYSA-N |
NSC 74859 (S3I-201) is a chemical probe inhibitor of STAT3 with an IC50 offor STAT3 DNA-binding activity in cell-free assays, displaying low activity against STAT1 and STAT5. It disrupts STAT3-STAT3 complex formation and blocks STAT3-mediated transcriptional activity. Consequently, NSC 74859 downregulates STAT3 target genes including cyclin D1, Bcl-xL, and survivin, suppressing cell proliferation, inducing apoptosis, and inhibiting human breast tumor growth in vivo. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
73 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
73 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
73 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
| DMSO |
73 mg/mL
(199.8 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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