CAS No. 122320-73-4

Batch: Purity:99.99
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Rosiglitazone (BRL 49653) Chemical Structure
Chemical Structure
Check the Rosiglitazone (BRL 49653) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
CAS Number 122320-73-4
Molecular Formula

C18H19N3O3S
Molecular Weight (MW) 357.43
SMILES CN(CCOC1=CC=C(C=C1)CC2C(=O)NC(=O)S2)C3=CC=CC=N3
InChIKey YASAKCUCGLMORW-UHFFFAOYSA-N

Ordering Information

Biological Activity

Rosiglitazone (BRL 49653) is a thiazolidinedione antihyperglycemic agent and selective peroxisome proliferator-activated receptor gamma (PPARγ) agonist. Activation of PPARγ regulates gene expression involved in lipid and glucose metabolism, promoting terminal adipocyte differentiation and enhancing insulin sensitivity. Additionally, rosiglitazone modulates TRP channels, induces autophagy, and prevents ferroptosis, thereby lowering blood glucose concentrations and exerting anti-inflammatory effects. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (198.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.