CAS No. 61379-65-5

Batch: Purity:97
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Rifapentine Chemical Structure
Chemical Structure
Check the Rifapentine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-[(E)-(4-cyclopentylpiperazin-1-yl)iminomethyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
CAS Number 61379-65-5
Molecular Formula

C47H64N4O12
Molecular Weight (MW) 877.03
SMILES CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)C=NN5CCN(CC5)C6CCCC6)C
InChIKey WDZCUPBHRAEYDL-GZAUEHORSA-N

Biological Activity

Rifapentine is a cyclopentyl rifamycin antibiotic that acts as a potent inhibitor of bacterial DNA-dependent RNA polymerase. By selectively binding to bacterial RNA polymerase, it effectively blocks transcription and suppresses RNA synthesis, leading to the inhibition of protein production and potent antibacterial action against Mycobacterium tuberculosis. This selective bacterial transcription inhibition effectively spares host eukaryotic cellular mechanisms. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (114.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Arioli V, et al. J Antibiot (Tokyo). 1981;34(8):1026-32.

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Note: Technical data last updated: Sep 1, 2026.