Clinical Trials

Rifampin has been evaluated across numerous clinical trials spanning Early Phase 1 through Phase 4 for conditions including pulmonary tuberculosis, HIV co-infections, COVID-19 pneumonia, solid tumors, Alzheimer's disease, and healthy volunteer pharmacokinetic profiles. Sponsored by major academic centers and pharmaceutical leaders, these studies encompass completed, active, recruiting, and terminated statuses. Phase 1 trials frequently utilize rifampin as a standard CYP3A inducer to evaluate drug-drug interactions, whereas Phase 3 studies examine combined therapeutic regimens in tuberculosis management.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07345325 RECRUITING
Infective Endocarditis
Nantes University Hospital
 2026-06-11 PHASE3
NCT03474029 RECRUITING
Latent Tuberculosis
Centers for Disease Control and Prevention
 2019-08-01 PHASE2; PHASE3
NCT07253688 RECRUITING
Staphylococcus Aureus Endocarditis; Prosthetic Valve Endocarditis
Todd C. Lee MD MPH FIDSA
 2025-11-10 PHASE3
NCT07595042 NOT_YET_RECRUITING
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2026-10-30 PHASE2
NCT06590428 RECRUITING
Rifampin-resistant Tuberculosis; Drug-resistant Tuberculosis
Albert Einstein College of Medicine
 2026-04-07
NCT06497465 RECRUITING
Tuberculosis; HIV
Johns Hopkins University
 2025-09-18 PHASE3
NCT06917495 NOT_YET_RECRUITING
Mild Spinal Tuberculosis
Shandong University
 2025-04-05 PHASE2
NCT06318416 RECRUITING
Tuberculosis
University of Virginia
 2025-10-01 PHASE1
NCT03301038 RECRUITING
Idiopathic Infantile Hypercalcaemia - Severe Form; Genetic Disease; Hypercalcemia, Idiopathic, of Infancy; Hypercalciuric Hypercalcemia; Idiopathic Infantile Hypercalcemia - Mild Form; Hypercalciuria
Children's Hospital of Philadelphia
 2018-07-25 PHASE2
NCT06253715 RECRUITING
Tuberculosis; Tuberculosis, Pulmonary; Tuberculosis, Lymph Node; Mycobacterium Tuberculosis
Johns Hopkins University
 2025-01-15 PHASE3
NCT07313215 RECRUITING
Periprosthetic Joint Infection
First Affiliated Hospital of Fujian Medical University
 2025-11-13
NCT06498414 RECRUITING
Tuberculosis Infection, Latent
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2025-06-10 PHASE2; PHASE3
NCT07800897 NOT_YET_RECRUITING
Healthy Female Adults
Bristol-Myers Squibb
 2026-08-26 PHASE1
NCT07600775 NOT_YET_RECRUITING
Human Immunodeficiency Virus (HIV); HIV Pre-Exposure Prophylaxis
Merck Sharp & Dohme LLC
 2026-09-01 PHASE1
NCT05766267 ACTIVE_NOT_RECRUITING
Tuberculosis, Pulmonary; Tuberculosis Infection
Centers for Disease Control and Prevention
 2023-11-21 PHASE2; PHASE3
NCT07357610 RECRUITING
Healthy Adult Participants
Jiangsu Simcere Pharmaceutical Co., Ltd.
 2026-01-05 PHASE1
NCT07770217 NOT_YET_RECRUITING
Healthy Participants
Jiangsu Hansoh Pharmaceutical Co., Ltd.
 2026-08-02 PHASE1
NCT06022146 RECRUITING
Tuberculosis; Latent Tuberculosis
Huashan Hospital
 2023-09-01 PHASE3
NCT07374224 RECRUITING
Clinical Pharmacology
Guangzhou Lupeng Pharmaceutical Company LTD.
 2026-03-05 PHASE1
NCT06222372 RECRUITING
Leprosy
Annemieke Geluk
 2020-03-04
NCT07550621 NOT_YET_RECRUITING
Healthy Volunteers (HV)
MindRank AI Ltd
 2026-05-06 PHASE1
NCT06489431 ACTIVE_NOT_RECRUITING
Erectile Dysfunction; Penile Prosthesis; Complications, Infection or Inflammation
Rush University Medical Center
 2023-12-04 PHASE3
NCT07242781 TERMINATED
Healthy Volunteers
Celgene
 2025-12-15 PHASE1
NCT07170800 RECRUITING
Tuberculosis; Multidrug Resistant Pulmonary Tuberculosis; Rifampicin-resistant Tuberculosis
WestVac Biopharma Co., Ltd.
 2025-09-19 PHASE2
NCT07330531 NOT_YET_RECRUITING
Drug-drug Interaction Study
Xuanzhu Biopharmaceutical Co., Ltd.
 2026-01-04 PHASE4
NCT03672630 COMPLETED
Mycobacterium Avium Complex; Nontuberculous Mycobacterium Infection
Kevin Winthrop
 2019-02-22 PHASE2; PHASE3
NCT07697157 COMPLETED
Health, Subjective
Hutchmed
 2025-03-01 PHASE1
NCT04921943 RECRUITING
Nontuberculous Mycobacterial Lung Disease; Nontuberculous Mycobacterium Infection
Oregon Health and Science University
 2021-05-18 PHASE4
NCT04951986 ACTIVE_NOT_RECRUITING
Disseminated Tuberculosis; HIV
University of Cape Town
 2021-08-11 PHASE3
NCT03012529 COMPLETED
Osteomyelitis; Diabetes; Amputation
VA Office of Research and Development
 2018-01-22 PHASE4
NCT06701136 NOT_YET_RECRUITING
Rifampicin-Resistant Pulmonary Tuberculosis Patients
Shanghai Jiatan Pharmatech Co., Ltd
 2025-05-12 PHASE1
NCT07018635 COMPLETED
Healthy Participants
Incyte Corporation
 2025-07-16 PHASE1
NCT07056842 COMPLETED
Obesity &Amp; Overweight
Vincentage Pharma Co., Ltd
 2025-07-20 PHASE1
NCT03731559 RECRUITING
HIV/TB Coinfection
The HIV Netherlands Australia Thailand Research Collaboration
 2019-06-25 PHASE2
NCT05454345 UNKNOWN
Tuberculosis, Pulmonary
First Affiliated Hospital of Zhejiang University
 2022-10-01 PHASE3
NCT06835465 COMPLETED
Healthy Participants
Genentech, Inc.
 2025-02-21 PHASE1
NCT06363630 COMPLETED
Healthy Volunteers
Celgene
 2024-04-23 PHASE1
NCT06332053 UNKNOWN
Healthy Subjects
Shouyao Holdings (Beijing) Co. LTD
 2024-04-01 PHASE1
NCT06348290 UNKNOWN
Solid Tumor, Adult
Jemincare
 2024-04-01 PHASE1
NCT05221502 COMPLETED
Pulmonary TB
Otsuka Pharmaceutical Development & Commercialization, Inc.
 2022-04-12 PHASE2
NCT02906007 COMPLETED
Tuberculosis; HIV
National Institute of Allergy and Infectious Diseases (NIAID)
 2017-09-21 PHASE1; PHASE2
NCT06031454 COMPLETED
Drug Drug Interaction
Guangdong Raynovent Biotech Co., Ltd
 2023-09-01 PHASE1
NCT05592223 COMPLETED
Tuberculosis
Fred Hutchinson Cancer Center
 2022-12-06 PHASE1
NCT05899829 COMPLETED
Cough; Healthy
Bellus Health Inc. - a GSK company
 2023-06-21 PHASE1
NCT05826574 COMPLETED
Healthy Volunteers
Insmed Incorporated
 2023-05-10 PHASE1
NCT05431673 UNKNOWN
Rhinoscleroma
Assiut University
 2022-08-21 PHASE1
NCT05635110 COMPLETED
Pain
Vertex Pharmaceuticals Incorporated
 2022-12-15 PHASE1
NCT05586568 UNKNOWN
Healthy Subjects
Xuanzhu Biopharmaceutical Co., Ltd.
 2022-11-15 PHASE1
NCT04537715 COMPLETED
All Malignancies; Advanced Malignancies; Hematologic Malignancy; Solid Tumor; Follicular Lymphoma (FL); Non-Hodgkin Lymphoma (NHL); Diffuse Large B-Cell Lymphoma (DLBCL); Epithelioid Sarcoma (ES); Synovial Sarcoma; Renal Medullary Carcinoma; Mesothelioma; Rhabdoid Tumor
Epizyme, Inc.
 2020-04-23 PHASE1
NCT05685719 COMPLETED
COVID-19 Pneumonia
Zhejiang ACEA Pharmaceutical Co. Ltd.
 2023-01-04 PHASE1
NCT05720767 COMPLETED
Relapsed or Refractory Lymphoma
Hutchmed
 2022-11-04 PHASE1
NCT03988933 COMPLETED
Latent Tuberculosis
McGill University Health Centre/Research Institute of the McGill University Health Centre
 2019-09-20 PHASE2
NCT05685719 Completed
COVID-19 Pneumonia
Zhejiang ACEA Pharmaceutical Co. Ltd.
 2023-01-04 Phase 1
NCT04768231 UNKNOWN
Tuberculosis
Hospital Universitari Vall d'Hebron Research Institute
 2021-04-01 PHASE2
NCT05635110 Completed
Pain
Vertex Pharmaceuticals Incorporated
 2022-12-15 Phase 1
NCT05389722 COMPLETED
Healthy Volunteers
Bristol-Myers Squibb
 2022-06-09 PHASE1
NCT05602597 COMPLETED
Relapsed or Refractory Lymphoma
Hutchmed
 2022-06-01 PHASE1
NCT05497674 COMPLETED
Type 2 Diabetes Mellitus
Sunshine Lake Pharma Co., Ltd.
 2022-02-21 PHASE1
NCT03174184 COMPLETED
Tuberculosis, Pulmonary
Johns Hopkins University
 2017-08-23 PHASE2
NCT05255276 COMPLETED
Healthy Adults
Mirati Therapeutics Inc.
 2022-02-02 PHASE1
NCT02256696 COMPLETED
Pulmonary Tuberculosis
Johns Hopkins University
 2015-04-29 PHASE2
NCT04463680 COMPLETED
Contraception; Tuberculosis
University of Colorado, Denver
 2020-09-23 PHASE4
NCT05057949 COMPLETED
Healthy Volunteers
Sunshine Lake Pharma Co., Ltd.
 2021-11-24 PHASE1
NCT05098041 COMPLETED
Healthy Volunteers
Takeda
 2021-11-22 PHASE1
NCT05359055 COMPLETED
Drug Drug Interaction
Shanghai Pharmaceuticals Holding Co., Ltd
 2021-12-13 PHASE1; PHASE2
NCT05316857 COMPLETED
Healthy Person
Beijing InnoCare Pharma Tech Co., Ltd.
 2021-12-16 PHASE1
NCT03384121 UNKNOWN
Idiopathic Infantile Hypercalcemia - Mild Form
The Hospital for Sick Children
 2018-02-22 PHASE1
NCT02547116 WITHDRAWN
Cystic Fibrosis; MRSA
Johns Hopkins University
 2020-12 PHASE4
NCT05098041 Completed
Healthy Volunteers
Takeda
 2021-11-22 Phase 1
NCT03173053 TERMINATED
Staphylococcus Aureus; Motility Disorder
Radboud University Medical Center
 2018-02-08
NCT02563327 COMPLETED
Tuberculosis
Centers for Disease Control and Prevention
 2016-01-25 PHASE3
NCT04933682 COMPLETED
Healthy
Alexion Pharmaceuticals, Inc.
 2021-06-07 PHASE1
NCT04843540 COMPLETED
Healthy Volunteers
Concert Pharmaceuticals
 2021-05-19 PHASE1
NCT04268394 COMPLETED
Healthy Volunteer
Celgene
 2020-03-13 PHASE1
NCT04933682 Completed
Healthy
Alexion Pharmaceuticals Inc.
 2021-06-23 Phase 1
NCT04843449 COMPLETED
Healthy
Ascletis Pharmaceuticals Co., Ltd.
 2021-04-04 PHASE1
NCT04565574 COMPLETED
Healthy Participants
Eisai Co., Ltd.
 2020-10-16 PHASE1
NCT03982277 COMPLETED
Tuberculosis
Makerere University
 2019-04-30 PHASE2
NCT04558216 WITHDRAWN
Healthy Participants
Phathom Pharmaceuticals, Inc.
 2020-09-30 PHASE1
NCT04290390 COMPLETED
Women; Contraception
TherapeuticsMD
 2020-02-12 PHASE1
NCT04410094 COMPLETED
Healthy
Janssen Research & Development, LLC
 2020-09-14 PHASE1
NCT04649723 COMPLETED
Healthy Subjects, Drug-drug Interaction, Pharmacokinetics, SHR1459
Jiangsu HengRui Medicine Co., Ltd.
 2020-11-24 PHASE1
NCT02019875 COMPLETED
Vitamin D and Calcium Homeostasis
University of Washington
 2014-06 EARLY_PHASE1
NCT04606537 COMPLETED
Healthy; Drug Drug Interaction
KBP Biosciences
 2020-10-24 PHASE1
NCT05134337 COMPLETED
Healthy Volunteers
Loxo Oncology, Inc.
 2020-02-12 PHASE1
NCT04557397 COMPLETED
Drug Drug Interaction
Hutchison Medipharma Limited
 2020-09-02 PHASE1
NCT04312282 TERMINATED
Advanced Solid Tumors
Odonate Therapeutics, Inc.
 2020-03-06 PHASE1
NCT04510649 COMPLETED
Healthy
Hutchison Medipharma Limited
 2020-07-09 PHASE1
NCT04266509 COMPLETED
Healthy Volunteers
Pfizer
 2020-06-25 PHASE1
NCT04577885 COMPLETED
Healthy
Jiangsu HengRui Medicine Co., Ltd.
 2020-05-28 PHASE1
NCT00585195 COMPLETED
Non-Small Cell Lung Cancer ALK-positive; Non-Small Cell Lung Cancer c-Met Dependent; Non-Small Cell Lung Cancer ROS Marker Positive; Systemic Anaplastic Large-Cell Lymphoma; Advanced Malignancies Except Leukemia
Pfizer
 2006-04-19 PHASE1
NCT04029584 COMPLETED
Drug-drug Interaction
University of California, San Francisco
 2019-04-25 PHASE4
NCT04301310 WITHDRAWN
Healthy Participants
Bristol-Myers Squibb
 2020-03-09 PHASE1
NCT04166669 COMPLETED
Fungal Infection
Basilea Pharmaceutica
 2019-11-12 PHASE1
NCT04142762 COMPLETED
Chronic Hepatitis B
Assembly Biosciences
 2019-10-18 PHASE1
NCT01438515 COMPLETED
Methicillin-resistant Staphylococcus Aureus
Horizon Health Network
 2008-08
NCT05577624 COMPLETED
Healthy Participants
Amgen
 2019-11-05 PHASE1
NCT04121078 COMPLETED
Healthy Volunteers
Millennium Pharmaceuticals, Inc.
 2019-10-15 PHASE1
NCT03983239 COMPLETED
Healthy Volunteers
Celgene
 2019-06-21 PHASE1
NCT03994211 COMPLETED
Solid Tumor
BeiGene
 2019-05-29 PHASE1
NCT04006353 COMPLETED
Drug Interaction
Shanghai Public Health Clinical Center
 2019-07-11 PHASE4
NCT03709355 COMPLETED
HIV-1-infection
Viriom
 2018-11-14 PHASE1
NCT03928327 COMPLETED
Healthy Volunteers
Millennium Pharmaceuticals, Inc.
 2019-05-02 PHASE1
NCT03991312 COMPLETED
Healthy Volunteers
Agios Pharmaceuticals, Inc.
 2019-06-20 PHASE1
NCT03486314 COMPLETED
Advanced Solid Neoplasm
Millennium Pharmaceuticals, Inc.
 2018-08-13 PHASE1
NCT02024555 COMPLETED
Sarcoidosis; Antimycobacterial Therapy
Vanderbilt University
 2014-03 PHASE2
NCT03278483 COMPLETED
Diabetes Mellitus; Tuberculin (Skin Test) Positive
Instituto Nacional de Salud Publica, Mexico
 2019-02-28 PHASE4
NCT03758469 COMPLETED
Anesthesia; Sedation
Sichuan Haisco Pharmaceutical Group Co., Ltd
 2018-12-14 PHASE1
NCT03755778 COMPLETED
RSV Infection
Enanta Pharmaceuticals, Inc
 2018-11-29 PHASE1
NCT03723395 COMPLETED
Drug-drug Interaction
Seagen Inc.
 2018-09-17 PHASE1
NCT03637790 COMPLETED
Healthy
Pfizer
 2018-09-13 PHASE1
NCT02273765 COMPLETED
HIV-1 Infection; Tuberculosis
ANRS, Emerging Infectious Diseases
 2015-09-11 PHASE3
NCT01700790 TERMINATED
AIDS; Tuberculosis
University of Miami
 2016-02 PHASE4
NCT03712540 COMPLETED
Healthy Participants
Bristol-Myers Squibb
 2018-09-06 PHASE1
NCT02608034 COMPLETED
Metastatic Melanoma, BRAF V600 Mutation Positive
Genentech, Inc.
 2016-05-26 PHASE1
NCT03801746 COMPLETED
Drug Interaction Potentiation
Akebia Therapeutics
 2018-07-20 PHASE1
NCT03624959 COMPLETED
Healthy Volunteer
Celgene
 2018-06-20 PHASE1
NCT03311841 COMPLETED
Renal Insufficiency
Merck Sharp & Dohme LLC
 2018-03-01 PHASE1
NCT05338489 COMPLETED
Healthy
Eli Lilly and Company
 2018-05-11 PHASE1
NCT03563950 COMPLETED
Healthy Participants
Bristol-Myers Squibb
 2018-06-01 PHASE1
NCT02231229 COMPLETED
Tuberculosis
Assistance Publique - Hôpitaux de Paris
 2014-07-23 PHASE4
NCT03307252 COMPLETED
Healthy
Boehringer Ingelheim
 2017-10-25 PHASE1
NCT02057796 COMPLETED
HIV-1 Infection
ANRS, Emerging Infectious Diseases
 2014-09 PHASE4
NCT02253420 COMPLETED
Medical Oncology
Bayer
 2014-10-08 PHASE1
NCT03340662 COMPLETED
Healthy Volunteer
Celgene
 2017-11-09 PHASE1
NCT01594827 COMPLETED
Cystic Fibrosis
Johns Hopkins University
 2012-10 PHASE2
NCT03346837 COMPLETED
Malignancies Multiple
Bristol-Myers Squibb
 2017-11-22 PHASE1
NCT03077607 COMPLETED
Advanced Solid Tumors
Pfizer
 2016-11-07 PHASE1
NCT03296800 COMPLETED
Type 2 Diabetes Mellitus
Theracos
 2017-09-27 PHASE1
NCT03301181 COMPLETED
Healthy Volunteers: Asian, Non-Asian
BeiGene
 2017-09-18 PHASE1
NCT03622918 COMPLETED
Colistin; Rifampin; Acinetobacter Infections
Gangnam Severance Hospital
 2016-10-27
NCT03213145 COMPLETED
NASH - Nonalcoholic Steatohepatitis
Enanta Pharmaceuticals, Inc
 2017-07-11 PHASE1
NCT03116893 COMPLETED
Healthy
Boehringer Ingelheim
 2017-04-19 PHASE1
NCT02576366 COMPLETED
Drug Interactions; Kidney Transplantation
Universitaire Ziekenhuizen KU Leuven
 2016-06 PHASE4
NCT00931736 COMPLETED
Latent Tuberculosis Infection
McGill University
 2009-08 PHASE3
NCT01601626 TERMINATED
HIV Infection; Tuberculosis
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2013-07-13 PHASE2
NCT02957448 COMPLETED
Atherothrombotic Diseases
Bristol-Myers Squibb
 2016-11 PHASE1
NCT02959060 COMPLETED
Thrombosis
Bristol-Myers Squibb
 2016-11 PHASE1
NCT02804399 COMPLETED
Healthy
Pfizer
 2016-07 PHASE1
NCT02820935 COMPLETED
Pharmacokinetics
Celgene Corporation
 2016-07 PHASE1
NCT02106767 COMPLETED
Healthy
University of California, San Francisco
 2014-11 PHASE1
NCT02809768 COMPLETED
Healthy Participants
Eisai Inc.
 2016-04 PHASE1
NCT02372383 COMPLETED
Cystic Fibrosis
University of Colorado, Denver
 2014-10
NCT02846519 COMPLETED
Healthy
Janssen Research & Development, LLC
 2016-02-26 PHASE1
NCT01408914 COMPLETED
Tuberculosis
Harvard University Faculty of Medicine
 2013-09 PHASE2
NCT01757236 UNKNOWN
Hip Prosthetic Joint Infection
University Hospital, Tours
 2012-10 PHASE2
NCT00802802 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2010-02-10 PHASE1
NCT01954043 COMPLETED
Cancer
GlaxoSmithKline
 2013-12-20 PHASE1
NCT02661893 COMPLETED
Healthy
Janssen Research & Development, LLC
 2016-01 PHASE1
NCT01765543 COMPLETED
Malignant Melanoma, Neoplasms
Hoffmann-La Roche
 2013-07 PHASE1
NCT02411435 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2015-07 PHASE1
NCT02500667 COMPLETED
Drug Interaction Potentiation
Nivalis Therapeutics, Inc.
 2015-06 PHASE1
NCT02430545 COMPLETED
Healthy Volunteers
Pfizer
 2015-05 PHASE1
NCT02097953 COMPLETED
Drug Interactions; Pharmacokinetics
University of Utah
 2014-05 EARLY_PHASE1
NCT01269541 COMPLETED
Throatcarriers of MRSA
Region Skane
 2011-03-01
NCT01454076 COMPLETED
Nonhematologic Malignancies; Lymphoma
Millennium Pharmaceuticals, Inc.
 2011-11-10 PHASE1
NCT02409004 COMPLETED
Healthy
PTC Therapeutics
 2015-02 PHASE1
NCT02807116 COMPLETED
Healthy Subjects
CTI BioPharma
 2015-01 PHASE1
NCT01380080 COMPLETED
HIV Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
 2011-10 PHASE4
NCT01349192 TERMINATED
Cystic Fibrosis; Methicillin-resistant Staphylococcus Aureus
University of North Carolina, Chapel Hill
 2011-04 PHASE2
NCT02286635 COMPLETED
Healthy Volunteers
PTC Therapeutics
 2014-11 PHASE1
NCT02256267 COMPLETED
Healthy Volunteers
Eli Lilly and Company
 2014-10 PHASE1
NCT00170209 COMPLETED
Latent Tuberculosis Infection
McGill University
 2011-08 PHASE3
NCT04914936 COMPLETED
Healthy Participants
Acerta Pharma BV
 2014-09-21 PHASE1
NCT02275962 COMPLETED
Healthy
Kowa Research Institute, Inc.
 2014-09 PHASE1
NCT01844583 COMPLETED
Solid Tumors; Lymphoma
Millennium Pharmaceuticals, Inc.
 2013-06-25 PHASE1
NCT02174250 COMPLETED
Parkinson's Disease
Kyowa Kirin Co., Ltd.
 2014-06 PHASE1
NCT01756924 TERMINATED
Prosthetic Joint Infections of Hip; Prosthetic Joint Infections of Knee; Infected Spacers
Arrevus Inc.
 2012-12 PHASE2
NCT01144000 UNKNOWN
Staphylococcal Infections
Andrej Trampuz
 2012-06 PHASE2
NCT01969682 WITHDRAWN
Non-Hodgkin's Lymphoma
AbbVie
 2014-04 PHASE1
NCT02085967 COMPLETED
Healthy Subjects
Eisai Inc.
 2014-02 PHASE1
NCT02055703 COMPLETED
Healthy Subjects
Eisai Inc.
 2014-01 PHASE1
NCT01576575 COMPLETED
Healthy
Washington University School of Medicine
 2010-06
NCT01953731 COMPLETED
Healthy
Pfizer
 2013-10 PHASE1
NCT01516203 COMPLETED
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2012-12-05 PHASE2
NCT01395654 UNKNOWN
Hepatitis; Tuberculosis, Pulmonary
National Taiwan University Hospital
 2011-07 PHASE4
NCT01398618 UNKNOWN
Latent Tuberculosis Infection
National Taiwan University Hospital
 2011-05 PHASE3
NCT01947777 COMPLETED
Healthy
SecuraBio
 2013-10 PHASE1
NCT01940510 COMPLETED
Healthy Volunteer
Hoffmann-La Roche
 2013-10 PHASE1
NCT01908582 COMPLETED
Healthy Volunteers
Eli Lilly and Company
 2013-07 PHASE1
NCT01768663 COMPLETED
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
 2013-01 PHASE1
NCT02138799 COMPLETED
Drug-Drug Interaction (DDI); Healthy Subjects; Pharmacokinetics of Enzalutamide
Astellas Pharma Europe B.V.
 2013-07 PHASE1
NCT01814709 COMPLETED
Healthy Volunteer
Genentech, Inc.
 2013-04 PHASE1
NCT02507167 COMPLETED
Gastrointestinal Hormones
University Medicine Greifswald
 2012-11 PHASE1
NCT01447511 COMPLETED
Healthy
University of Minnesota
 2009-05
NCT00814671 COMPLETED
Tuberculosis
Johns Hopkins University
 2010-04 PHASE2
NCT01571414 COMPLETED
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2012-05 PHASE1
NCT00877591 COMPLETED
Opioid Dependency; HIV Infections
University of California, San Francisco
 2008-04 PHASE1
NCT00728507 TERMINATED
Tuberculosis
Johns Hopkins University
 2009-11 PHASE2
NCT01763021 COMPLETED
Healthy Participants
Janssen Research & Development, LLC
 2012-12 PHASE1
NCT00423982 UNKNOWN
Prosthesis-related Infections; Staphylococcal Infections
Oslo University Hospital
 2006-04 PHASE4
NCT00771498 COMPLETED
HIV Infection; Tuberculosis
Oswaldo Cruz Foundation
 2008-11 PHASE4
NCT01273480 COMPLETED
Neoplasm Metastases
Janssen Research & Development, LLC
 2010-12 PHASE1
NCT01637636 COMPLETED
Healthy
Vanda Pharmaceuticals
 2012-06 PHASE1
NCT01218620 COMPLETED
Adult Solid Neoplasm
National Cancer Institute (NCI)
 2010-09 PHASE1
NCT01341184 COMPLETED
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2011-10-21 PHASE1
NCT01026415 COMPLETED
Carcinomas; Disease, Hodgkin; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Neoplasms
Seagen Inc.
 2009-12 PHASE1
NCT01533870 COMPLETED
Drug Induced Constipation
AstraZeneca
 2012-03 PHASE1
NCT01561963 COMPLETED
Healthy Subjects
Amgen
 2012-02-01 PHASE1
NCT01441206 TERMINATED
Infection
University of North Carolina, Chapel Hill
 2011-09 PHASE1
NCT01324323 COMPLETED
Hematologic Malignancy; Malignant Lymphoma
Celgene
 2011-04-01 PHASE1
NCT01932268 COMPLETED
Chronic Kidney Disease; Tuberculosis
Seoul National University Hospital
 2011-01 PHASE2
NCT00822315 COMPLETED
HIV Infections; Tuberculosis
ANRS, Emerging Infectious Diseases
 2009-07 PHASE2
NCT01231542 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
 2011-05 PHASE1
NCT01401933 COMPLETED
Advanced Solid Tumors
Abbott
 2011-05 PHASE1
NCT01500837 COMPLETED
Osteoarticular Infection
Assistance Publique - Hôpitaux de Paris
 2010-10
NCT00964106 COMPLETED
Drug Interactions
GlaxoSmithKline
 2009-08-26 PHASE1
NCT01395927 COMPLETED
Healthy
Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
 2011-07 PHASE1
NCT01363804 COMPLETED
Healthy
AVEO Pharmaceuticals, Inc.
 2011-05 PHASE1
NCT01063270 COMPLETED
Hidradenitis Suppurativa
Henry Ford Health System
 2010-02
NCT01322438 COMPLETED
Neoplasms
Bayer
 2011-03 PHASE1
NCT01121133 COMPLETED
Lymphoma, Including Chronic Lymphocytic Leukemia; Solid Tumors
AbbVie
 2010-05 PHASE1
NCT01162486 COMPLETED
Tuberculosis; Tuberculosis, Pulmonary
Johns Hopkins University
 2010-04 PHASE1
NCT01251835 WITHDRAWN
Pulmonary Arterial Hypertension
Pfizer
 2010-12 PHASE1
NCT00767975 COMPLETED
Tuberculosis
National Taiwan University Hospital
 2008-01 PHASE3
NCT01169038 COMPLETED
Pulmonary Sarcoidosis; Lung Function
Vanderbilt University
 2010-07 PHASE1
NCT01204112 COMPLETED
Healthy
Pfizer
 2010-09 PHASE1
NCT01002079 COMPLETED
Alzheimer Disease
Bristol-Myers Squibb
 2010-08 PHASE1
NCT01147055 COMPLETED
Healthy
Pfizer
 2010-07 PHASE1
NCT01068756 TERMINATED
Type 2 Diabetes Mellitus
AstraZeneca
 2010-03 PHASE1
NCT00439166 COMPLETED
Alzheimer's Disease
Hamilton Health Sciences Corporation
 2007-02 PHASE3
NCT01018368 COMPLETED
Cystic Fibrosis
Vertex Pharmaceuticals Incorporated
 2009-11 PHASE1
NCT00935363 WITHDRAWN
Healthy
University of California, San Francisco
 2010-02 PHASE1
NCT00568711 COMPLETED
Scrub Typhus
Dong-Min Kim
 2006-09
NCT00715858 UNKNOWN
Alzheimer's Disease
McMaster University
 2008-05 PHASE3
NCT00864487 COMPLETED
Healthy Subjects
Puma Biotechnology, Inc.
 2009-04 PHASE1
NCT00777855 COMPLETED
Healthy
University of California, San Francisco
 2008-11
NCT00741169 COMPLETED
Hepatitis C; HCV; Tuberculosis; Rifampin; Pharmacokinetics
Tibotec Pharmaceuticals, Ireland
 2008-06 PHASE1
NCT00776516 COMPLETED
Pharmacokinetics of YM178
Astellas Pharma Inc
 2008-10 PHASE1
NCT00483054 COMPLETED
HIV Infections; Tuberculosis
Bamrasnaradura Infectious Diseases Institute
 2007-01 PHASE3
NCT00207090 COMPLETED
Advanced Solid Tumors; Neoplasms
R-Pharm
 2005-09 PHASE1
NCT00057122 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2002-09 PHASE3
NCT00534807 WITHDRAWN
Cancer
Bristol-Myers Squibb
 2007-09 PHASE1
NCT00128206 COMPLETED
Tuberculosis
University of California, San Francisco
 2004-11 PHASE3
NCT00130247 COMPLETED
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2002-04-08 PHASE3
NCT00476853 COMPLETED
HIV Infections; Tuberculosis
The HIV Netherlands Australia Thailand Research Collaboration
 2005-10 PHASE2
NCT00351273 COMPLETED
Arthritis, Reactive; Reiter Disease
University of South Florida
 2006-05 PHASE3
NCT01082276 COMPLETED
Male, Healthy Normal Subjects
Sumitomo Pharma America, Inc.
 2008-08 PHASE1
NCT00725426 COMPLETED
Healthy
Wyeth is now a wholly owned subsidiary of Pfizer
 2008-07 PHASE1
NCT00144417 COMPLETED
Tuberculosis
Centers for Disease Control and Prevention
 2006-02 PHASE2
NCT00405080 COMPLETED
Nausea and Vomiting, Chemotherapy-Induced
GlaxoSmithKline
 2006-11-11 PHASE1
NCT00304811 COMPLETED
Staphylococcus Aureus
Michael E. DeBakey VA Medical Center
 2006-01 PHASE4
NCT00023374 COMPLETED
Tuberculosis
Centers for Disease Control and Prevention
 2000-08
NCT00418756 COMPLETED
Healthy
Novartis Pharmaceuticals
 2006-10 PHASE1
NCT00598962 COMPLETED
Mycobacterium Avium Complex
The University of Texas Health Science Center at Tyler
 1994-12 PHASE4
NCT00384280 COMPLETED
Healthy
Wyeth is now a wholly owned subsidiary of Pfizer
 2006-09 PHASE1
NCT00182429 COMPLETED
Clostridium Enterocolitis; Antibiotic-Associated Diarrhea; Pseudomembranous Colitis; Pseudomembranous Enterocolitis; Pseudomembranous Enteritis
McMaster University
 2004-02 PHASE3
NCT00000950 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00000638 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00004689 COMPLETED
Mycobacterium Avium-intracellulare Infection
National Jewish Health
 1991-01 PHASE2
NCT00096850 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001033 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE3
NCT00402610 COMPLETED
HIV Infections; Tuberculosis
Sociedad Andaluza de Enfermedades Infecciosas
 1994-01 PHASE4
NCT00127504 COMPLETED
Onchocerciasis
Centers for Disease Control and Prevention
 2003-07 PHASE2
NCT00140309 COMPLETED
Tuberculosis, Pulmonary
Centers for Disease Control and Prevention
 2003-07 PHASE2
NCT00023335 COMPLETED
Pulmonary Tuberculosis
Centers for Disease Control and Prevention
 1995-04 PHASE3
NCT00043264 COMPLETED
Multiple Sclerosis
National Center for Research Resources (NCRR)
 PHASE2
NCT00000636 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00317330 COMPLETED
Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
 2004-12 PHASE3
NCT00000641 COMPLETED
Mycobacterium Avium-intracellulare Infection; HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
 PHASE2
NCT00402454 COMPLETED
HIV Infections
Sociedad Andaluza de Enfermedades Infecciosas
 1994-01 PHASE4
NCT00397709 TERMINATED
Tuberculosis
Hospital Virgen de la Luz
 1996-03 PHASE4
NCT00000796 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)

(data from https://clinicaltrials.gov, updated on 2026-07-28)

Check the Rifampin (Rifampicin) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Rifampin selectively binds to the beta subunit of bacterial DNA-dependent RNA polymerase, thereby blocking transcription initiation and suppressing bacterial RNA synthesis. This bactericidal mechanism leads to cell death, providing the biological rationale for its clinical use in clearing *Mycobacterium tuberculosis* infections in tuberculosis trial populations.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

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Note: Technical data last updated: Sep 1, 2026.