CAS No. 36791-04-5

Batch: Purity:99.89
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Ribavirin (ICN-1229) Chemical Structure
Chemical Structure
Check the Ribavirin (ICN-1229) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
CAS Number 36791-04-5
Molecular Formula

C8H12N4O5
Molecular Weight (MW) 244.20864
SMILES C1=NC(=NN1C2C(C(C(O2)CO)O)O)C(=O)N
InChIKey IWUCXVSUMQZMFG-AFCXAGJDSA-N

Biological Activity

Ribavirin is a synthetic guanosine analogue and antiviral agent targeting cellular inosine monophosphate dehydrogenase (IMPDH) and viral RNA-dependent RNA polymerases. Inhibition of IMPDH by ribavirin 5'-monophosphate depletes intracellular GTP pools and disrupts RNA metabolism required for viral replication. Additionally, ribavirin enhances host T-cell-mediated immunity against viral infections by shifting the T-cell immune response from a type 2 to a type 1 phenotype. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 49 mg/mL (200.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 49 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Graci JD, et al. Rev Med Virol. 2006;16(1):37-48.

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Note: Technical data last updated: Sep 1, 2026.