CAS No. 196597-26-9

Batch: Purity:99.92
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Ramelteon Chemical Structure
Chemical Structure
Check the Ramelteon product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[2-[(8S)-2,6,7,8-tetrahydro-1H-cyclopenta[e][1]benzofuran-8-yl]ethyl]propanamide
CAS Number 196597-26-9
Molecular Formula

C16H21NO2
Molecular Weight (MW) 259.34
SMILES CCC(=O)NCCC1CCC2=C1C3=C(C=C2)OCC3
InChIKey YLXDSYKOBKBWJQ-LBPRGKRZSA-N

Biological Activity

Ramelteon (TAK-375) is a selective melatonin receptor agonist targeting the human MT1 receptor (Ki = and human MT2 receptor (Ki = 112 pM). By selectively binding to MT1 and MT2 receptors, ramelteon regulates master circadian rhythms and promotes sleep without demonstrating affinity for GABA receptor complexes or other neurotransmitter systems. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 51 mg/mL (196.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 51 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Kato K, et al. Neuropharmacology. 2005;48(2):301-10.

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Note: Technical data last updated: Sep 1, 2026.