CAS No. 111974-72-2

Batch: Purity:99.98
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Quetiapine (ICI-204636) fumarate Chemical Structure
Chemical Structure
Check the Quetiapine (ICI-204636) fumarate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name bis(2-[2-(4-benzo[b][1,4]benzothiazepin-6-ylpiperazin-1-yl)ethoxy]ethanol);(E)-but-2-enedioic acid
CAS Number 111974-72-2
Molecular Formula

C46H54N6O8S2
Molecular Weight (MW) 883.09
SMILES C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C1CN(CCN1CCOCCO)C2=NC3=CC=CC=C3SC4=CC=CC=C42.C(=CC(=O)O)C(=O)O
InChIKey ZTHJULTYCAQOIJ-WXXKFALUSA-N

Ordering Information

Biological Activity

Quetiapine fumarate is an atypical antipsychotic agent that functions as a multi-receptor antagonist targeting serotonin, dopamine, histamine, and adrenergic receptors. By inhibiting dopamine D2 and serotonin 5-HT2A receptor signaling, it modulates central neurotransmitter pathways, suppressing hyperdopaminergic signaling and altering downstream neuronal excitability. These receptor interactions regulate cell-mediated neurochemical pathways and key signaling cascades governing behavioral and physiological phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 36 mg/mL (40.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.