CAS No. 22204-24-6
Batch:
Purity:99.99
Chemical Structure
Check the
Pyrantel Pamoate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;1-methyl-2-[(E)-2-thiophen-2-ylethenyl]-5,6-dihydro-4H-pyrimidine | |
|---|---|---|
| CAS Number | 22204-24-6 | |
| Molecular Formula |
C23H16O6.C11H14N2S |
|
| Molecular Weight (MW) | 594.692 | |
| SMILES | CN1CCCN=C1C=CC2=CC=CS2.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O | |
| InChIKey | AQXXZDYPVDOQEE-MXDQRGINSA-N |
Biological Activity
Pyrantel pamoate is a broad-spectrum anthelmintic agent and depolarizing neuromuscular blocking agent that acts as an agonist of nicotinic acetylcholine receptors. Activation of these receptors induces persistent membrane depolarization in parasite muscle tissue. This sustained excitation leads to neuromuscular blockade and spastic paralysis, ultimately resulting in the detachment and expulsion of parasitic intestinal worms. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(168.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.