CAS No. 60-82-2

Batch: Purity:99.96
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Phloretin (RJC 02792) Chemical Structure
Chemical Structure
Check the Phloretin (RJC 02792) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
CAS Number 60-82-2
Molecular Formula

C15H14O5
Molecular Weight (MW) 274.27
SMILES C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
InChIKey VGEREEWJJVICBM-UHFFFAOYSA-N

Ordering Information

Biological Activity

Phloretin is a natural dihydrochalcone polyphenol that acts as an inhibitor of glucose transporter 1 (GLUT1). By blocking GLUT1-mediated glucose transport, phloretin impairs cellular glucose uptake and disrupts glycolytic flux. This inhibition suppresses downstream cell proliferation and triggers apoptosis in cancer cell models. Furthermore, phloretin modulates signaling cascades, including the NF-kB and STAT3 pathways, to attenuate inflammatory responses and inhibit tumor growth. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 55 mg/mL (200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 55 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.