CAS No. 63-92-3
| IUPAC Name | N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine;hydrochloride | |
|---|---|---|
| CAS Number | 63-92-3 | |
| Molecular Formula |
C18H22ClNO.HCl |
|
| Molecular Weight (MW) | 340.3 | |
| SMILES | CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl | |
| InChIKey | VBCPVIWPDJVHAN-UHFFFAOYSA-N |
Phenoxybenzamine HCl is a non-specific, irreversible alpha-adrenergic receptor antagonist. By forming a permanent covalent bond with adrenergic receptors, it prevents the binding of endogenous ligands including adrenaline and noradrenaline. This irreversible receptor blockade inhibits alpha-1 adrenoceptor signaling in vascular smooth muscle cells, effectively blocking signal transduction and downstream vasoconstriction. Consequently, this antagonism leads to sustained vasodilatation and reduced vascular tone. [1]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(199.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 68 mg/mL |
| Water | 17 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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