CAS No. 914913-88-5

Batch: Purity:99.49
Check CoA
Palomid 529 (P529) Chemical Structure
Chemical Structure
Check the Palomid 529 (P529) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]benzo[c]chromen-6-one
CAS Number 914913-88-5
Molecular Formula

C24H22O6
Molecular Weight (MW) 406.43
SMILES CC(C1=CC2=C(C=C1)C3=CC(=C(C=C3OC2=O)OCC4=CC=C(C=C4)OC)OC)O
InChIKey YEAHTLOYHVWAKW-UHFFFAOYSA-N

Biological Activity

Palomid 529 is an inhibitor of both the mTORC1 and mTORC2 complexes, targeting the PI3K/Akt/mTOR signaling pathway. By dual targeting of TORC1 and TORC2, it suppresses downstream phosphorylation of Akt at Ser473, GSK3β at Ser9, and ribosomal protein S6. Consequently, Palomid 529 inhibits endothelial cell proliferation, vascular permeability, and tumor angiogenesis, while inducing apoptosis and enhancing radiation-mediated antiproliferative effects. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 81 mg/mL (199.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Free Aliquotting Service

Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.

Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.

Reference

[1] Diaz-ChavezJ, et al. Mol Cancer. 2008;7(1).

[2] Gravina GL, et al. Endocr Relat Cancer. 2011;18(4):385-400.

Jump to

Note: Technical data last updated: Sep 1, 2026.