CAS No. 144598-75-4

Batch: Purity:99.94
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Paliperidone Chemical Structure
Chemical Structure
Check the Paliperidone product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
CAS Number 144598-75-4
Molecular Formula

C23H27FN4O3
Molecular Weight (MW) 426.48
SMILES CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
InChIKey PMXMIIMHBWHSKN-UHFFFAOYSA-N

Ordering Information

Biological Activity

Paliperidone is an atypical antipsychotic compound that acts as a potent antagonist of serotonin 5-HT2A and dopamine D2 receptors. By blocking serotonin 5-HT2A and dopamine D2 receptor-mediated signaling, it modulates monoaminergic signal transduction and downstream neurotransmitter pathways. This receptor antagonism inhibits dopaminergic hyperactivity in mesolimbic pathways, thereby regulating neuronal network excitability and cellular signaling in central nervous system circuits.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
5%TFA 15 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.