CAS No. 775304-57-9
Chemical Information
| CAS Number | 775304-57-9 | |
|---|---|---|
| Molecular Formula |
C15H9FN2O3 |
|
| Molecular Weight (MW) | 284.24 | |
| SMILES | C1=CC=C(C(=C1)C2=NC(=NO2)C3=CC(=CC=C3)C(=O)O)F |
Biological Activity
Ataluren (PTC124) is an orally bioavailable small-molecule readthrough agent that selectively targets ribosomal premature termination codons. By promoting translational readthrough without affecting normal stop codons or mRNA stability, Ataluren restores the production of full-length, functional proteins in cell and animal models harboring nonsense mutations. This targeted suppression of premature translational termination rescues downstream protein function and restores normal cellular phenotypes across various genetic disease models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
| Solvent | Solubility & Note |
|---|---|
| DMSO |
57 mg/mL
(200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
57 mg/mL
(200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
57 mg/mL
(200.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.