CAS No. 1092788-83-4
Batch:
Purity:99.21
Chemical Structure
Check the
PP121
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine | |
|---|---|---|
| CAS Number | 1092788-83-4 | |
| Molecular Formula |
C17H17N7 |
|
| Molecular Weight (MW) | 319.36 | |
| SMILES | C1CCC(C1)N2C3=NC=NC(=C3C(=N2)C4=CN=C5C(=C4)C=CN5)N | |
| InChIKey | NVRXTLZYXZNATH-UHFFFAOYSA-N |
PP121 is a multitargeted dual kinase inhibitor targeting both receptor tyrosine kinases and phosphoinositide 3-kinase (PI3K) family enzymes, including p110α, mTOR, DNA-PK, PDGFR, VEGFR2, Src, and Abl. By simultaneously targeting tyrosine kinase and PI3K/mTOR signaling cascades, PP121 blocks the phosphorylation of downstream effectors such as Akt, p70S6K, and S6. This dual pathway inhibition suppresses cancer cell proliferation and survival. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
32 mg/mL
(100.2 mM)
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.