CAS No. 167869-21-8
Batch:
Purity:99.92
Chemical Structure
Check the
PD 98059
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(2-amino-3-methoxyphenyl)chromen-4-one | |
|---|---|---|
| CAS Number | 167869-21-8 | |
| Molecular Formula |
C16H13NO3 |
|
| Molecular Weight (MW) | 267.28 | |
| SMILES | COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2 | |
| InChIKey | QFWCYNPOPKQOKV-UHFFFAOYSA-N |
PD 98059 is a selective, non-ATP competitive MEK inhibitor that suppresses MEK1 (IC50 of and MEK2 (IC50 of activation. By preventing the phosphorylation and activation of MEK by upstream kinases, it blocks downstream MAPK/ERK pathway signaling. This inhibition suppresses cell proliferation, migration, and differentiation without directly inhibiting ERK1 or ERK2. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
46 mg/mL
(172.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
53 mg/mL
(198.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
14 mg/mL
(52.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
28 mg/mL
(104.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
14 mg/mL
(52.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.