CAS No. 7240-38-2

Batch: Purity:99.85
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Oxacillin sodium monohydrate Chemical Structure
Chemical Structure
Check the Oxacillin sodium monohydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 7240-38-2
Molecular Formula

C19H18N3O5S.Na.H2O
Molecular Weight (MW) 441.43
SMILES CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].O.[Na+]

Biological Activity

Oxacillin sodium monohydrate is a narrow-spectrum, penicillinase-resistant beta-lactam antibiotic that targets bacterial penicillin-binding proteins (PBPs). By acylating the active site of PBPs, it inhibits the transpeptidation step of peptidoglycan synthesis essential for cell wall assembly. This disruption leads to structural instability, osmotic lysis, and bacterial cell death, demonstrating potent antibacterial activity against susceptible Gram-positive pathogens such as Staphylococcus aureus. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 88 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Fuda C, et al. J Biol Chem. 2004;279(39):40802-6.

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Note: Technical data last updated: Sep 1, 2026.