Nutlin-3 is a potent and selective MDM2 inhibitor. It affects p53 signaling by binding to the p53-binding pocket of MDM2 to disrupt the MDM2-p53 interaction, effectively promoting p53 stabilization, cell cycle arrest, and apoptosis in cancer cells.
Nutlin-3: Mechanism of Action
Nutlin-3 MOA：Targeting MDM2/p53 Pathway for Oncology